2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Ziv-aflibercept

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases.

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Ziv-aflibercept

Ziv-aflibercept Chemische Struktur

CAS. Nr. : 1609655-49-3

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Ziv-aflibercept Related Antibodies

Top Publications Citing Use of Products

Alle VEGFR Isoform-spezifische Produkte anzeigen:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Beschreibung

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2].

Species Reactivity

Human
In Vitro

Ziv-aflibercept (0.25, 0.5, 1.0 and 5 mg/mL; 24 h) reduces mitochondrial membrane potential in ARPE-19 cells with dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziv-aflibercept Related Antibodies

Cell Viability Assay[1]

Cell Line: ARPE-19 cells.
Concentration: 0.25, 0.5, 1.0 and 5 mg/mL.
Incubation Time: 24 h.
Result: Insignificantly affected cell viability (below 1 mg/mL).
In Vivo

Ziv-aflibercept (25 mg/mL; intravitreal injection; single dose) insignificantly causes cataract, retinal detachment and other related complications in the right eye of the rabbit[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molekulargewicht

96.9 kDa

CAS. Nr.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ziv-aflibercept]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Ziv-aflibercept Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziv-aflibercept1609655-49-3VEGFRVascular endothelial growth factor receptorARPE-19 cellsRabbitInhibitorinhibitorinhibit

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