2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA/RNA Synthesis ADC Payload
  4. ε-Amanitin

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II.

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ε-Amanitin

ε-Amanitin Chemical Structure

CAS No. : 21705-02-2

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ε-Amanitin Related Antibodies

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Description

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].

IC50 & Target[1]

RNA Polymerase

 

Traditional Cytotoxic Agents

 

In Vitro

Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ε-Amanitin Related Antibodies
Masse moléculaire

903.96

Formule

C39H53N9O14S
CAS No.
SMILES

O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(O)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O
Structure Classification
Initial Source

alba mushroom
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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ε-Amanitin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ε-Amanitin21705-02-2DNA/RNA SynthesisADC PayloadADC CytotoxinsynthesismRNAbiosynthesiscellularapoptosiscyclicpeptideInhibitorinhibitorinhibit

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