1. Metabolic Enzyme/Protease
    GPCR/G Protein
    Anti-infection
  2. Acyltransferase
    Angiotensin Receptor
    Bacterial
  3. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone 

Cat. No.: HY-N9530
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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL.

For research use only. We do not sell to patients.

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone Chemical Structure

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone Chemical Structure

CAS No. : 120693-53-0

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Description

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL[1][2][3].

IC50 & Target

IC50: 20.1 μM (diacylglycerol acyltransferase)[3], 34.1 μM (angiotensin II receptor)[2]

In Vitro

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL[1].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC50 of 20.1 μM[3].
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC50 of 10.1 μM[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

337.50

Formula

C₂₃H₃₁NO

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
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HY-N9530
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