Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus

  • Biol Pharm Bull. 1999 Oct;22(10):1141-3. doi: 10.1248/bpb.22.1141.
T C Rho  1 ,  E A Bae ,  D H Kim ,  W K Oh ,  B Y Kim ,  J S Ahn ,  H S Lee
Affiliations
  • 1. Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.
PMID: 10549874 DOI: 10.1248/bpb.22.1141
Abstract

A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone Alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolo ne (3), 1-methyl-2-undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl-4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. However, they had no effect on Helicobacter pylori Urease activity at the concentration of 300 microg/ml.

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