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Helicobacter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Angiotensin Receptor (1) Antibiotic (2) Apoptosis (1) Bacterial (24) DNA/RNA Synthesis (1) Endogenous Metabolite (4) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (1) PKC (1) Proton Pump (2) Reactive Oxygen Species (1) SARS-CoV (1) STAT (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (3) Infection (25) Inflammation/Immunology (3) Metabolic Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120536

HPi1	Bacterial	Infection
HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC₅₀ of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum .

HY-162149

Urease-IN-12	Bacterial	Infection
Urease-IN-12 (compound 5e) is a competitive urease inhibitor (IC₅₀: 0.35 μM) with the potential to inhibit gastritis and peptic ulcer caused by Helicobacter pylori .

HY-N10820

Psoracorylifol C	Bacterial	Infection
Psoracorylifol C is a natural product. Psoracorylifol C has important activity against Helicobacter pylori. Psoracorylifol C can be isolated from the seeds of Psoralea corylifolia .

HY-N10456

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Bacterial	Infection
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

HY-135759

Cetraxate	Others	Infection
Cetraxate is an orally active antiulcer Drug. Cetraxate increases the blood flow of gastric mucosal. Cetraxate increases the eradication of Helicobacter pylori in smokers when in combination with Omeprazole (HY-B0113),Amoxicillin (HY-B0467A), and Clarithromycin (HY-17508) .

HY-E70058

*α-1-3,4 Fucosyltransferase, helicobacter* pylori** α-1-3,4 FucT; Hp3/4FT	Endogenous Metabolite	Metabolic Disease
alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (EC 2.4.1.65) (Hp3/4FT) can be found in Helicobacter pylori. alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) catalyzes fucose transfer from donor GDP-beta-l-fucose to the GlcNAc .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Acyltransferase Angiotensin Receptor Bacterial	Infection Cardiovascular Disease Metabolic Disease
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-123204

FR182024

Bacterial Infection

FR182024 is a cephem derivative with potent anti-Helicobacter pylori activities .
HY-N6975

Glyasperin D

Bacterial Infection

Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .

FR182024	Bacterial	Infection
FR182024 is a cephem derivative with potent anti-Helicobacter pylori activities .

Glyasperin D	Bacterial	Infection
Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .

HY-N0207

Patchouli alcohol 1 Publications Verification	Bacterial	Infection Inflammation/Immunology Cancer
Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties .

HY-117760

Spirolaxine	Bacterial Endogenous Metabolite	Infection
Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .

HY-N11054

Psoracorylifol B

Bacterial Infection

Psoracorylifol B is a Helicobacter pylori inhibitor with MICs of both 12.5 μg/mL against H. pylori ATCC 43504 and H. pylori SS1 .

Psoracorylifol B	Bacterial	Infection
Psoracorylifol B is a Helicobacter pylori inhibitor with MICs of both 12.5 μg/mL against H. pylori ATCC 43504 and H. pylori SS1 .

HY-B0691A

Ecabet sodium TA-2711
Ecabet sodium (TA-2711) is currently applied to some gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication . Ecabet sodium reduces apoptosis .

HY-155521

Enzyme-IN-2

Bacterial Infection

Enzyme-IN-2 (compound 15) is a ureases inhibitor (K_i=2.36 μM) with anti-ureolytic activity (IC₅₀=0.75 μM) .

Enzyme-IN-2	Bacterial	Infection
Enzyme-IN-2 (compound 15) is a ureases inhibitor (K_i=2.36 μM) with anti-ureolytic activity (IC₅₀=0.75 μM) .

HY-N3386

Licoricone	Bacterial	Infection
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-B0691

Ecabet	Reactive Oxygen Species Bacterial	Infection
Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication . Ecabet sodium reduces apoptosis

HY-N10211

Saccharothrixin K	Bacterial Endogenous Metabolite	Infection
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL .

HY-16102

Bismuth subcitrate potassium	Bacterial Antibiotic	Infection
Bismuth subcitrate potassium is an antibiotic against 12 C. pyloridis strains with MIC₅₀ of 8 ug/ml . Bismuth subcitrate potassium is used to treat diseases of the upper gastrointestinal tract infected with Helicobacter pylori .

HY-118877

Urea-13C	Isotope-Labeled Compounds	Infection
Urea- ¹³C is the ¹³C labelled urea. The Urea- ¹³C breath test ( ¹³C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection[1].

HY-B0643

Dirithromycin 1 Publications Verification LY237216	Bacterial Antibiotic	Infection
Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis .

HY-125130

Hesperetin 7-O-glucoside	HMG-CoA Reductase (HMGCR) Bacterial	Infection Metabolic Disease
Hesperetin 7-O-glucoside is produced by the enzymatic conversion of Hesperidin. Hesperetin 7-O-glucoside is a potent human HMG-CoA reductase inhibitor and also effectively inhibits the growth of Helicobacter pylori. Antihypertensive effect .

HY-141488

Lacto-N-biose I Galβ1-3GlcNAc	Endogenous Metabolite	Endocrinology
Lacto-N-biose I (Galβ1-3GlcNAc), as an endogenous metabolite, is an acceptor for the α1,2-fucosyltransferase enzyme from Helicobacter pylori .

HY-N9203

Pinobanksin 5-methyl ether	Bacterial	Infection
Pinobanksin 5-methyl ether can be isolated from Georgian Propolises. Pinobanksin 5-methyl ether has anti-helicobacter activity. Pinobanksin 5-methyl ether is effective inducer of CYP9Q enzyme .

HY-N2040

(20R)-Protopanaxadiol
(20R)-Protopanaxadiol is a triterpenoid saponin metabolite of 20(R)-ginsenoside Rg3 in black ginseng. (20R)-Protopanaxadiol exhibits anti-tumor activity and cytotoxicity, and potently inhibits the growth of Helicobacter pylori .

HY-N8306

Isojacareubin	Bacterial PKC Apoptosis SARS-CoV	Cancer
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis .

HY-106789

Plaunotol CS-684	Bacterial	Infection Inflammation/Immunology Cancer
Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .

HY-N3142

Oleuropeic acid 8-O-glucoside	Bacterial	Infection
Oleuropeic acid 8-O-glucoside is a terpenic compound, that can be isolated from twigs with leaves of Juniperus communis var. depressa. Oleuropeic acid 8-O-glucoside shows antibacterial activity against three strains of Helicobacter pylori (NCTC11637, NCTC11916, and OCO1), with MIC of 100 μg/mL all .

HY-B0693A

Ranitidine bismuth citrate
Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC₉₀ value of 16 ng/L .

HY-148706

STAT3-IN-17	STAT	Infection Cancer
STAT3-IN-17 is a moderate STAT3 inhibitor (IC₅₀=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori .

HY-100007A

Vonoprazan hydrochloride TAK-438 hydrochloride	Proton Pump Bacterial	Infection Endocrinology
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori .

HY-100007

Vonoprazan 3 Publications Verification TAK-438 free base	Proton Pump Bacterial	Endocrinology
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H ⁺,K ⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .

HY-105099

Rifalazil KRM-1648; ABI-1648	DNA/RNA Synthesis Bacterial	Infection Inflammation/Immunology
Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .

alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA)	Biochemical Assay Reagents
alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA) is an acetylgalactose aminotransferase, which can be isolated from Helicobacter mustelae, and can specifically recognize Fucα1,2-Gal epitopes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0207

Patchouli alcohol 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Labiatae Sesquiterpenes Source classification Plants Picris hieracioides L. Inflammation/Immunology Disease Research Fields Cancer	Bacterial
Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties .

HY-N10820

Psoracorylifol C	Structural Classification Microorganisms Leguminosae Source classification Coumarins Phenylpropanoids Psoralea corylifolia L. Plants	Bacterial
Psoracorylifol C is a natural product. Psoracorylifol C has important activity against Helicobacter pylori. Psoracorylifol C can be isolated from the seeds of Psoralea corylifolia .

HY-N10456

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone	Natural Products Source classification Rutaceae Plants Tetradium ruticarpum (A. Jussieu) T. G. Hartley	Bacterial
1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone is a potent antibacterial agent with an MIC₅₀ value of 22 µM and an MIC₉₀ value of 50 µM for Helicobacter pyloriStrain 51. 1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone has the potential for the research of gastric and duodenal ulcers .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Acyltransferase Angiotensin Receptor Bacterial
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-N6975

Glyasperin D	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Bacterial
Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .

HY-117760

Spirolaxine	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial Endogenous Metabolite
Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .

HY-N11054

Psoracorylifol B	Structural Classification Microorganisms Leguminosae Terpenoids Sesquiterpenes Source classification Psoralea corylifolia L. Plants	Bacterial
Psoracorylifol B is a Helicobacter pylori inhibitor with MICs of both 12.5 μg/mL against H. pylori ATCC 43504 and H. pylori SS1 .

HY-N3386

Licoricone	Infection Flavonoids Monophenols Classification of Application Fields Leguminosae Source classification Phenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Bacterial
Licoricone is an flavonoid extracted from licorice, exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains .

HY-N10211

Saccharothrixin K	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial Endogenous Metabolite
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL .

HY-125130

Hesperetin 7-O-glucoside	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Phenols Polyphenols Metabolic Disease Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	HMG-CoA Reductase (HMGCR) Bacterial
Hesperetin 7-O-glucoside is produced by the enzymatic conversion of Hesperidin. Hesperetin 7-O-glucoside is a potent human HMG-CoA reductase inhibitor and also effectively inhibits the growth of Helicobacter pylori. Antihypertensive effect .

HY-141488

Lacto-N-biose I Galβ1-3GlcNAc	Polysaccharides Microorganisms Classification of Application Fields Source classification Disease Research Fields Saccharides Endocrinology	Endogenous Metabolite
Lacto-N-biose I (Galβ1-3GlcNAc), as an endogenous metabolite, is an acceptor for the α1,2-fucosyltransferase enzyme from Helicobacter pylori .

HY-N9203

Pinobanksin 5-methyl ether	Infection Structural Classification Flavanonols Flavonoids Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial
Pinobanksin 5-methyl ether can be isolated from Georgian Propolises. Pinobanksin 5-methyl ether has anti-helicobacter activity. Pinobanksin 5-methyl ether is effective inducer of CYP9Q enzyme .

HY-N8306

Isojacareubin	Structural Classification Flavonoids Flavones Source classification Guttiferae Plants Hypericum japonicum Thunb. ex Murray	Bacterial PKC Apoptosis SARS-CoV
Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis .

HY-N3142

Oleuropeic acid 8-O-glucoside	Structural Classification Cupressaceae Juniperus communis L. Ketones, Aldehydes, Acids Source classification Plants Saccharides Monosaccharides	Bacterial
Oleuropeic acid 8-O-glucoside is a terpenic compound, that can be isolated from twigs with leaves of Juniperus communis var. depressa. Oleuropeic acid 8-O-glucoside shows antibacterial activity against three strains of Helicobacter pylori (NCTC11637, NCTC11916, and OCO1), with MIC of 100 μg/mL all .

Tag:	His (2) Tag Free (1) GST (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P701331

	*vacA Protein, Helicobacter* pylori (His)** Vacuolating cytotoxin autotransporter	Others	E. coli
	The VacA protein takes center stage, demonstrating its unique ability to induce vacuole formation in eukaryotic cells, affecting cell morphology. This process involves the formation of vacuoles, highlighting the role of VacA as a key regulator of cell structure. vacA Protein, Helicobacter pylori (His) is the recombinant vacA protein, expressed by E. coli , with N-6*His labeled tag. The total length of vacA Protein, Helicobacter pylori (His) is 209 a.a., with molecular weight of 26.6 kDa.

HY-P702129

	*HELPY Protein, Helicobacter* pylori** Glutathione hydrolase proenzyme	Others	E. coli
	HpGT Protein, Helicobacter pylori is a glutathione-degrading enzyme that is a virulence factor in infection. Glutathione hydrolase proenzyme belongs to the gamma-glutamyltransferase family. pylorigamma-glutamyltranspeptidase is expressed as a 60-kDa inactive precursor that must undergo autocatalytic processing to generate a 40-kDa/20-kDa heterodimer with full gamma-glutamyl amide bond hydrolase activity. HpGT Protein, Helicobacter pylori is the recombinant HpGT protein, expressed by E. coli , with tag free. The total length of HpGT Protein, Helicobacter pylori is 543 a.a., .

HY-P702130

	*HELPY Protein, Helicobacter* pylori (His)** Glutathione hydrolase proenzyme	Others	E. coli
	HpGT Protein, Helicobacter pylori is a glutathione-degrading enzyme that is a virulence factor in infection. Glutathione hydrolase proenzyme belongs to the gamma-glutamyltransferase family. pylorigamma-glutamyltranspeptidase is expressed as a 60-kDa inactive precursor that must undergo autocatalytic processing to generate a 40-kDa/20-kDa heterodimer with full gamma-glutamyl amide bond hydrolase activity. HELPY Protein, Helicobacter pylori (His) is the recombinant HpGT protein, expressed by E. coli , with N-6*His labeled tag. The total length of HELPY Protein, Helicobacter pylori (His) is 543 a.a., .

HY-P700388

	*HP-0175 Protein, Helicobacter* pylori (GST)** Rotamase HP_0175; Putative peptidyl-prolyl cis-trans isomerase HP_0175	Others	E. coli
	HP-0175 is an antigen secreted by Helicobacter pylori. HP-0175 provides a link between helicobacter pylori-associated inflammation and gastric cancer by promoting the pro-inflammatory low-cytotoxic TIL response, stromal degradation, and pro-angiogenesis pathways. HP-0175 relies on the unfolded protein response (UPR) to autophagy in gastric epithelial cells and induce apoptosis. HP-0175 Protein, Helicobacter pylori (GST) is the recombinant HP-0175 protein, expressed by E. coli , with N-GST labeled tag. The total length of HP-0175 Protein, Helicobacter pylori (GST) is 278 a.a., with molecular weight of 58.8 kDa.

Cat. No.	Product Name	Chemical Structure

HY-118877

Urea-13C

Urea- ¹³C is the ¹³C labelled urea. The Urea- ¹³C breath test ( ¹³C-UBT) is one of the best methods for the diagnosis of Helicobacter pylori infection[1].

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Helicobacter

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products