Bismuth subcitrate potassium
Based on 1 Customer Validation
Bismuth subcitrate potassium is a compound bismuth salt with oral activity. Bismuth subcitrate potassium has antibacterial activity and can inhibit the growth of Campylobacter pyloridis with a MIC50 of 8 μg/mL. Bismuth subcitrate potassium can be used in the study of gastrointestinal diseases infected by Campylobacter pyloridis.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 880149-29-1
- Formula: C12H8BiK5O14
- Molecular Weight:780.66
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
MIC50: 8 μg/mL (C. pyloridis)[1]
Bismuth subcitrate potassium inhibits Helicobacter pylori, and can be used for a combination formulation (Pylera-Axcan) for ameliorating H. pylori infection and duodenal ulcer disease[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 880149-29-1
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Appearance Solid
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Molecular Weight 780.66
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Formula C12H8BiK5O14
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Color White to off-white
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SMILES
O=C(O[Bi](OC(CC(C(O[K])=O)(O[K])CC(O[K])=O)=O)OC1=O)C(C1)(O[K])CC(O[K])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (64.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Van Caekenberghe DL, et al. In vitro synergistic activity between bismuth subcitrate and various antimicrobial agents against Campylobacter pyloridis (C. pylori). Antimicrob Agents Chemother. 1987 Sep;31(9):1429-30. [Content Brief]
[2]. Malfertheiner P, et al. Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial. Lancet. 2011 Mar 12;377(9769):905-13. [Content Brief]
[3]. Hussar DA. New drugs: retapamulin, bismuth subcitrate potassium, and rotigotine. J Am Pharm Assoc (2003). 2007 Jul-Aug;47(4):539-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2810 mL | 6.4049 mL | 12.8097 mL | 32.0244 mL |
| 5 mM | 0.2562 mL | 1.2810 mL | 2.5619 mL | 6.4049 mL | |
| 10 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2024 mL | |
| 15 mM | 0.0854 mL | 0.4270 mL | 0.8540 mL | 2.1350 mL | |
| 20 mM | 0.0640 mL | 0.3202 mL | 0.6405 mL | 1.6012 mL | |
| 25 mM | 0.0512 mL | 0.2562 mL | 0.5124 mL | 1.2810 mL | |
| 30 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0675 mL | |
| 40 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8006 mL | |
| 50 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.6405 mL | |
| 60 mM | 0.0213 mL | 0.1067 mL | 0.2135 mL | 0.5337 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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