1. Anti-infection
  2. Bacterial
  3. HPi1

HPi1 

Cat. No.: HY-120536 Purity: >98.0%
Handling Instructions

HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum.

For research use only. We do not sell to patients.

HPi1 Chemical Structure

HPi1 Chemical Structure

CAS No. : 13080-21-2

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5 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1].

IC50 & Target

IC50: 0.24 μM (Helicobacter pylori)[1]
MIC: 0.08-0.16 μg/mL (Helicobacter pylori)[1]

In Vitro

The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL)[1].
HPi1 has some activity against the Bacteroides species, but at concentrations at least 18-fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL[1].
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T1/2 of 1.3 hours) and the ability to passively permeate membranes[1].

In Vivo

HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day[1].

Animal Model: Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension[1]
Dosage: 6.25 mg/kg, 12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration: Oral gavage; once a day; for 3 days
Result: Reduced colony counts to below the limit of detection.
Molecular Weight

192.24

Formula

C₈H₈N₄S

CAS No.

13080-21-2

SMILES

S=C1NC2=C(C=CC=C2)N=C1NN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (325.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2018 mL 26.0092 mL 52.0183 mL
5 mM 1.0404 mL 5.2018 mL 10.4037 mL
10 mM 0.5202 mL 2.6009 mL 5.2018 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

HPi1HPi 1HPi-1BacterialAntimicrobialorallyHelicobacterpyloripepticulcergastricpermeatemembranesInhibitorinhibitorinhibit

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HPi1
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HY-120536
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