Hesperetin 7-O-glucoside
Based on 1 publication(s) in Google Scholar
Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with Ki of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 31712-49-9
- Formula: C22H24O11
- Molecular Weight:464.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-17504A
Rosuvastatin
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HY-N0168
Hesperetin
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HY-13528
Clinofibrate
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HY-B0589
Atorvastatin
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HY-17504
Rosuvastatin Calcium
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HY-N0504
Lovastatin
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HY-B0144A
Pitavastatin
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HY-B0144
Pitavastatin Calcium
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HY-17504B
Rosuvastatin Sodium
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HY-17379
Atorvastatin hemicalcium salt
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HY-B0165A
Pravastatin sodium
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HY-N0504R
Lovastatin (Standard)
Publications Citing Use of MedChemExpress (MCE) Hesperetin 7-O-glucoside
More
Biological Activity
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IL-1β |
IL-22 |
Hesperetin 7-O-glucoside (0.05-0.5mM; 0-80 h) inhibits the growth of H. pylori[1].
Hesperetin 7-O-glucoside (5 μM; 12 h) down-regulates the mRNA level of inflammatory factor IL-1β in RAW264.7 cells treated with LPS (HY-D1056)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS (HY-D1056) treated RAW264.7 cells
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Concentration:5 μM
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Incubation Time:12 h
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Result:Reduced the level of IL-1β mRNA.
Hesperetin 7-O-glucoside (1-10 mg/kg; Oral gavage; 7 days) regulates intestinal flora and metabolic homeostasis in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dextran sodium sulfate (DSS) (HY-116282C) treated female C57BL/6N mice aged six weeks old (16-18 g)[2]
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Dosage:1 mg/kg
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Administration:Oral administration (p.o.); 7 days
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Result:Markedly alleviated the inflammatory status in DSS-induced colitis mice, manifested by the recovered colon length from 5.91± 0.66 to 6.45 ± 0.17 cm, histopathological changes, and mRNA levels of colonic inflammatory factors including TNF-α and IL-22.
Regulated the gut microbiota composition in the cecal contents and co-metabolites.
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Animal Model:Female C57BL/6N mice aged six weeks old (16-18 g)[3]
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Dosage:1, 5 and 10 mg/kg
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Administration:Oral gavage (i.g.); 7 days
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Result:Regulated fecal microbiota and its derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan metabolites (indole and its derivatives), in feces of mice.
Significantly changed urinary hippurate and trimethylamine Noxide (TMAO), co-metabolites of the microbe and host.
Modulated the host tricarboxylic acid cycle (TCA) involved in energy metabolism.
Chemical Information
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CAS No. 31712-49-9
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Appearance Solid
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Molecular Weight 464.42
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Formula C22H24O11
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Color White to off-white
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SMILES
O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
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Synonyms
Hes-7-G
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Food Chem
Unveiling multifunctional bioactive phytochemicals and antioxidants in tangerine pomace for value-added applications. [Abstract]2025 Nov 30;493(Pt 2):145781. PMID: 40774202
Solvent & Solubility
DMSO : 25 mg/mL (53.83 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Young-Su Lee, et al. Enzymatic Bioconversion of Citrus Hesperidin by Aspergillus Sojae Naringinase: Enhanced Solubility of hesperetin-7-O-glucoside With in Vitro Inhibition of Human Intestinal Maltase, HMG-CoA Reductase, and Growth of Helicobacter Pylori. Food Chem. 2012 Dec 15;135(4):2253-9. [Content Brief]
[2]. Wu F, et al. In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity. J Agric Food Chem. 2021 Nov 3;69(43):12753-12762. [Content Brief]
[3]. Wu F, et al. Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. J Agric Food Chem. 2021 Feb 10;69(5):1478-1486. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1532 mL | 10.7661 mL | 21.5322 mL | 53.8306 mL |
| 5 mM | 0.4306 mL | 2.1532 mL | 4.3064 mL | 10.7661 mL | |
| 10 mM | 0.2153 mL | 1.0766 mL | 2.1532 mL | 5.3831 mL | |
| 15 mM | 0.1435 mL | 0.7177 mL | 1.4355 mL | 3.5887 mL | |
| 20 mM | 0.1077 mL | 0.5383 mL | 1.0766 mL | 2.6915 mL | |
| 25 mM | 0.0861 mL | 0.4306 mL | 0.8613 mL | 2.1532 mL | |
| 30 mM | 0.0718 mL | 0.3589 mL | 0.7177 mL | 1.7944 mL | |
| 40 mM | 0.0538 mL | 0.2692 mL | 0.5383 mL | 1.3458 mL | |
| 50 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0766 mL |
Hesperetin 7-O-glucoside Related Classifications
HY-125130 Related Classifications
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