120693-53-0
Chemical Structure
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone
- CAS No.: 120693-53-0
- Formula:C23H31NO
- Molecular Weight:337.50
IUPAC Name: 1-methyl-2-((4Z,7Z)-trideca-4,7-dien-1-yl)quinolin-4(1H)-one
InChIKey: JYQCHQIQAURYAG-NQLNTKRDSA-N
SMILES: CN1C2=CC=CC=C2C(C=C1CCC/C=C\C/C=C\CCCCC)=O
Biological Activity: 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL[1][2][3].
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1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone | 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL. | |||||||||||||||||||||
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- [1]. Rho TC, et, al. Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus. Biol Pharm Bull. 1999 Oct;22(10):1141-3. [Content Brief]
- [2]. Lee HS, et, al. Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa. Phytotherapy Research. 1998 May; 12(3): 212-214.
- [3]. Ko JS, et, al. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Med. 2002 Dec;68(12):1131-3. [Content Brief]