2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2'-Deoxyuridine 5'-monophosphate disodium

2'-Deoxyuridine 5'-monophosphate disodium  (Synonyms: dUMP disodium)

Cat. No.: HY-W011142 Purity: 99.97%
COA
SDS
Handling Instructions Technical Support

2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis.

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2'-Deoxyuridine 5'-monophosphate disodium

2'-Deoxyuridine 5'-monophosphate disodium 화학구조

CAS No. : 42155-08-8

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
250 mg 해외재고보유
500 mg   견적 받기  
1 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of 2'-Deoxyuridine 5'-monophosphate disodium:

2'-Deoxyuridine 5'-monophosphate disodium Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

In Vitro

The compounds with anti-bacterial activity against the human pathogenic bacterium Helicobacter pylori markedly inhibit the NADPH oxidation and 2'-Deoxyuridine 5'-monophosphate (dUMP)-forming activities of HpThyX enzyme in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxyuridine 5'-monophosphate disodium Related Antibodies
분자량

352.15

화학식

C9H11N2Na2O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도
In Vitro: 

H2O : 233.33 mg/mL (662.59 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8397 mL 14.1985 mL 28.3970 mL
5 mM 0.5679 mL 2.8397 mL 5.6794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (283.97 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.97%

SDS (393 KB)

COA (252 KB) HNMR (259 KB) RP-HPLC (258 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.8397 mL 14.1985 mL 28.3970 mL 70.9925 mL
5 mM 0.5679 mL 2.8397 mL 5.6794 mL 14.1985 mL
10 mM 0.2840 mL 1.4198 mL 2.8397 mL 7.0992 mL
15 mM 0.1893 mL 0.9466 mL 1.8931 mL 4.7328 mL
20 mM 0.1420 mL 0.7099 mL 1.4198 mL 3.5496 mL
25 mM 0.1136 mL 0.5679 mL 1.1359 mL 2.8397 mL
30 mM 0.0947 mL 0.4733 mL 0.9466 mL 2.3664 mL
40 mM 0.0710 mL 0.3550 mL 0.7099 mL 1.7748 mL
50 mM 0.0568 mL 0.2840 mL 0.5679 mL 1.4198 mL
60 mM 0.0473 mL 0.2366 mL 0.4733 mL 1.1832 mL
80 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8874 mL
100 mM 0.0284 mL 0.1420 mL 0.2840 mL 0.7099 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2'-Deoxyuridine 5'-monophosphate disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyuridine 5'-monophosphate disodium42155-08-8dUMP disodiumEndogenous MetabolitedTMPDNA synthesisthymidylate synthaseInhibitorinhibitorinhibit

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상품명:
2'-Deoxyuridine 5'-monophosphate disodium
Cat. No.:
HY-W011142
수량:
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