2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Acipimox

Acipimox  (Synonyms: K-9321; アシピモックス)

製品番号: HY-B0283 純度: 99.58%
COA 取扱説明書 Technical Support

Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity.

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Acipimox

Acipimox 構造式

CAS 番号 : 51037-30-0

容量 価格（税別） 在庫状況 数量
50 mg $85 在庫あり
100 mg $120 在庫あり
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500 mg   お問い合わせ  

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Based on 2 publication(s) in Google Scholar

Other Forms of Acipimox:

Acipimox 関連抗体

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製品説明

Acipimox (K-9321), a nicotinic acid analogue, is an antilipolytic compound. Acipimox stimulates leptin releas, inhibits lipolysis and suppresses systemic levels of free fatty acids (FFAs) and improves insulin sensitivity[1][2][3].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
5.3 3
Compound: acipimox
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation
[PMID: 17358052]
CHO EC50
5.3 3
Compound: acipimox
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation
Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generation
[PMID: 17358052]
体外実験

Acipimox (0-100 μM; 0-4 hours) enhances leptin release from adipocytes isolated from Sprague-Dawley rats in a time- and dose- dependent manner[2].
Acipimox (10 mM) stimulats leptin release in adipocytes from Streptozotocin (STZ)-treated and Zucker diabetic fat (ZDF) rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acipimox 関連抗体
体内実験

Acipimox (50 mg/kg; i.p.) significantly lowers circulating free fatty acid (FFA) and glucose in high-fat fed mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice[3]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection
Result: Reduced circulating levels of FFA and glucose after 3 h.
臨床実験
分子量

154.12

分子式

C6H6N2O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C[N+]([O-])=C(C)C=N1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (648.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (129.76 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4882 mL 32.4412 mL 64.8824 mL
5 mM 1.2976 mL 6.4882 mL 12.9765 mL
10 mM 0.6488 mL 3.2441 mL 6.4882 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 46.67 mg/mL (302.81 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.4882 mL 32.4412 mL 64.8824 mL 162.2060 mL
5 mM 1.2976 mL 6.4882 mL 12.9765 mL 32.4412 mL
10 mM 0.6488 mL 3.2441 mL 6.4882 mL 16.2206 mL
15 mM 0.4325 mL 2.1627 mL 4.3255 mL 10.8137 mL
20 mM 0.3244 mL 1.6221 mL 3.2441 mL 8.1103 mL
25 mM 0.2595 mL 1.2976 mL 2.5953 mL 6.4882 mL
30 mM 0.2163 mL 1.0814 mL 2.1627 mL 5.4069 mL
40 mM 0.1622 mL 0.8110 mL 1.6221 mL 4.0552 mL
50 mM 0.1298 mL 0.6488 mL 1.2976 mL 3.2441 mL
60 mM 0.1081 mL 0.5407 mL 1.0814 mL 2.7034 mL
80 mM 0.0811 mL 0.4055 mL 0.8110 mL 2.0276 mL
100 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.6221 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acipimox Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acipimox51037-30-0K-9321K9321K 9321Carbonic AnhydraseCarbonate dehydrataseantilipolyticnicotinicacidanaloguederivativediabetesautonomictonelipolysisInhibitorinhibitorinhibit

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製品番号:
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