Dermorphin

Name: Dermorphin
Brand: MedChemExpress
SKU: HY-P0244
Rating: 4.5 (0 reviews)

Cat. No.: HY-P0244 Purity: 99.36%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Dermorphin 화학구조

CAS No. : 77614-16-5

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Dermorphin:

Dermorphin TFA 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Protocol
순도&문서
References
고객리뷰

제품 설명

Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain^[1].

IC₅₀ & Target

μ Opioid Receptor/MOR

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.72 nM Compound: dermorphin	Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation counting Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation counting	[PMID: 19621878]
CHO	IC₅₀	197 nM Compound: dermorphin	Displacement of [3H]DPDPE from delta opioid receptor expressed in CHO cells after 90 mins by scintillation counting Displacement of [3H]DPDPE from delta opioid receptor expressed in CHO cells after 90 mins by scintillation counting	[PMID: 19621878]
HEK293	IC₅₀	>10000 nM Compound: dermorphin	Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells	[PMID: 16814543]
HEK293	IC₅₀	>10 μM Compound: dermorphin	Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells	[PMID: 16814543]

In Vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO_hMu, Dermorphin and DeNo displac the binding of [³H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [³H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[³⁵S] in a concentration dependent and saturable manner at the Mu receptor^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

802.87

화학식

C₄₀H₅₀N₈O₁₀

CAS No.

77614-16-5

Appearance

Solid

Color

White to off-white

Sequence

Tyr-{d-Ala}-Phe-Gly-Tyr-Pro-Ser-NH2

Sequence Shortening

Y-{d-Ala}-FGYPS-NH2

Structure Classification

Others

Initial Source

Animals

skin of the frog Phyllomedusa sauvagei

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : ≥ 100 mg/mL (124.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2455 mL	6.2277 mL	12.4553 mL
5 mM	0.2491 mL	1.2455 mL	2.4911 mL
10 mM	0.1246 mL	0.6228 mL	1.2455 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (124.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.36%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (248 KB) LCMS (324 KB)

Handling Instructions (2659 KB)

References

[1]. Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20. [Content Brief]

[2]. Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897. [Content Brief]

Kinase Assay
^[2]

Membrane protein (40 μg) is incubated in 0.5 mL volume of 50 mM Tris, 0.2 mM EGTA, 1 mM MgCl₂, 100 mM NaCl, 0.1% BSA, 0.15 mM bacitracin; pH 7.4, GDP (33 μM), and ∼150 pM GTPγ[³⁵S]. Varying concentrations of reference ligands (Dermorphin, N/OFQ, Dynorphin-A and Leu-enkephalin) or DeNo (1 pM-10 μM) is added prior to incubation. Non-specific binding is determined in the presence of unlabeled GTPγS (10 μM). Samples are incubated at 30°C for 1 h with gentle agitation. Reactions are terminated by vacuum filtration through dry Whatman GF/B filters, using a Brandel harvester^[2].

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.

References

[1]. Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20. [Content Brief]

[2]. Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.2455 mL	6.2277 mL	12.4553 mL	31.1383 mL
	5 mM	0.2491 mL	1.2455 mL	2.4911 mL	6.2277 mL
	10 mM	0.1246 mL	0.6228 mL	1.2455 mL	3.1138 mL
	15 mM	0.0830 mL	0.4152 mL	0.8304 mL	2.0759 mL
	20 mM	0.0623 mL	0.3114 mL	0.6228 mL	1.5569 mL
	25 mM	0.0498 mL	0.2491 mL	0.4982 mL	1.2455 mL
	30 mM	0.0415 mL	0.2076 mL	0.4152 mL	1.0379 mL
	40 mM	0.0311 mL	0.1557 mL	0.3114 mL	0.7785 mL
	50 mM	0.0249 mL	0.1246 mL	0.2491 mL	0.6228 mL
	60 mM	0.0208 mL	0.1038 mL	0.2076 mL	0.5190 mL
	80 mM	0.0156 mL	0.0778 mL	0.1557 mL	0.3892 mL
	100 mM	0.0125 mL	0.0623 mL	0.1246 mL	0.3114 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Dermorphin Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dermorphin

고객리뷰

Other Forms of Dermorphin:

Dermorphin Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Opioid Receptor Isoform Specific Products:

Biological Activity

Protocol

순도&문서

References

고객리뷰

Dermorphin Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Dermorphin Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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