1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Dermorphin TFA

Dermorphin TFA 

Cat. No.: HY-P0244A
Handling Instructions

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

For research use only. We do not sell to patients.

Dermorphin TFA Chemical Structure

Dermorphin TFA Chemical Structure

CAS No. : 78331-26-7

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Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].

IC50 & Target

μ-opioid receptor (MOR)[1]

In Vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





OC(C=C1)=CC=C1C[[email protected]](NC(CNC([[email protected]@H](NC([[email protected]@H](C)NC([[email protected]@H](N)CC2=CC=C(O)C=C2)=O)=O)CC3=CC=CC=C3)=O)=O)C(N4[[email protected]@H](CCC4)C(N[[email protected]@H](CO)C(N)=O)=O)=O.OC(C(F)(F)F)=O


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DermorphinOpioid ReceptorNaturalheptapeptideopioidMORamphibianskinmu-opioidperipheralnervoussystemneuropathicpainwide-dynamicneuronganglionspinalnerveligationInhibitorinhibitorinhibit

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