1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Dermorphin TFA

Dermorphin TFA 

Cat. No.: HY-P0244A
Handling Instructions

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

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Dermorphin TFA Chemical Structure

Dermorphin TFA Chemical Structure

CAS No. : 78331-26-7

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Description

Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].

IC50 & Target

μ-opioid receptor (MOR)[1]

In Vitro

Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2].

Molecular Weight

916.90

Formula

C₄₂H₅₁F₃N₈O₁₂

CAS No.

78331-26-7

SMILES

OC(C=C1)=CC=C1C[[email protected]](NC(CNC([[email protected]@H](NC([[email protected]@H](C)NC([[email protected]@H](N)CC2=CC=C(O)C=C2)=O)=O)CC3=CC=CC=C3)=O)=O)C(N4[[email protected]@H](CCC4)C(N[[email protected]@H](CO)C(N)=O)=O)=O.OC(C(F)(F)F)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DermorphinOpioid ReceptorNaturalheptapeptideopioidMORamphibianskinmu-opioidperipheralnervoussystemneuropathicpainwide-dynamicneuronganglionspinalnerveligationInhibitorinhibitorinhibit

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Dermorphin TFA
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