Dolastatin 10 (Synonyms: DLS 10; NSC 376128)

Name: Dolastatin 10
Brand: MedChemExpress
SKU: HY-15580
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製品番号: HY-15580 純度: 98.34%: Data Sheet SDS COA 取扱説明書
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Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

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Dolastatin 10 構造式

CAS 番号 : 110417-88-4

容量	価格（税別）	在庫状況	数量
1 mg	$85	在庫あり	Estimated Time of Arrival: December 31
5 mg	$170	在庫あり	Estimated Time of Arrival: December 31
10 mg	$270	在庫あり	Estimated Time of Arrival: December 31
25 mg	$540	在庫あり	Estimated Time of Arrival: December 31
50 mg	$865	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1385	在庫あり	Estimated Time of Arrival: December 31
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製品説明

Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

IC₅₀ & Target

Auristatin

Cellular Effect

Cell Line	Type	Value	Description	References
A10	EC₅₀	0.25 1 Compound: 1	Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence	[PMID: 11473421]
OVCAR-3	GI₅₀	0.001 1 Compound: 1	Anticancer activity against human OVCAR-3 cells assessed as growth inhibition Anticancer activity against human OVCAR-3 cells assessed as growth inhibition	[PMID: 35072477]
A10	EC₅₀	0.25 1 Compound: 1	Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence	[PMID: 11473421]
A498	GI₅₀	0.033 1 Compound: 1	Anticancer activity against human A498 cells assessed as growth inhibition Anticancer activity against human A498 cells assessed as growth inhibition	[PMID: 35072477]
NCI-H460	GI₅₀	0.004 1 Compound: 1	Anticancer activity against human NCI-H460 cells assessed as growth inhibition Anticancer activity against human NCI-H460 cells assessed as growth inhibition	[PMID: 35072477]
BXPC-3	GI₅₀	0.051 1 Compound: 2	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28926240]
MCF7	GI₅₀	0.005 1 Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28895394]
BXPC-3	GI₅₀	0.051 1 Compound: 1	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28895394]
BXPC-3	GI₅₀	0.051 1 Compound: 1	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28895394]
DU-145	GI₅₀	0.007 1 Compound: 2	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28926240]
MCF7	GI₅₀	0.005 1 Compound: 2	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28926240]
BXPC-3	GI₅₀	0.051 1 Compound: 2	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28926240]
KM-20L2	GI₅₀	0.006 1 Compound: 1	Anticancer activity against human KM-20L2 cells assessed as growth inhibition Anticancer activity against human KM-20L2 cells assessed as growth inhibition	[PMID: 35072477]
DU-145	GI₅₀	0.007 1 Compound: 1	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28895394]
SF-268	GI₅₀	0.006 1 Compound: 1	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28895394]
CA46	IC₅₀	30 1 Compound: Dolastatin 10	Cytotoxicity against human CA46 cell line Cytotoxicity against human CA46 cell line	[PMID: 16837194]
HCT-116	IC₅₀	0.48 1 Compound: 1	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
SF-268	GI₅₀	0.006 1 Compound: 2	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28926240]
HCT-116	IC₅₀	24 1 Compound: 1	Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
DU-145	GI₅₀	0.007 1 Compound: 1	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28895394]
DU-145	GI₅₀	0.007 1 Compound: 1	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28895394]
HCT-116	IC₅₀	65 1 Compound: 1	Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
DU-145	GI₅₀	0.007 1 Compound: 2	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28926240]
DU-145	GI₅₀	0.007 1 Compound: 2	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 28926240]
HT-29	IC₅₀	0.06 1 Compound: 1	Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay	[PMID: 35072477]
SK-MEL-5	GI₅₀	0.009 1 Compound: 1	Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition	[PMID: 35072477]
KM-20L2	GI₅₀	0.01 1 Compound: 2	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28926240]
KM-20L2	GI₅₀	0.01 1 Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28895394]
KM-20L2	GI₅₀	0.01 1 Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28895394]
HCT-116	IC₅₀	0.48 1 Compound: 1	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
KM-20L2	GI₅₀	0.01 1 Compound: 2	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28926240]
L1210	IC₅₀	0.9 1 Compound: 1	Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs	[PMID: 35072477]
HCT-116	IC₅₀	24 1 Compound: 1	Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.01 1 Compound: 1	Cytotoxicity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition Cytotoxicity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition	[PMID: 35072477]
MCF7	GI₅₀	0.005 1 Compound: 2	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28926240]
HCT-116	IC₅₀	65 1 Compound: 1	Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
SF-295	GI₅₀	0.01 1 Compound: 1	Anticancer activity against human SF-295 cells assessed as growth inhibition Anticancer activity against human SF-295 cells assessed as growth inhibition	[PMID: 35072477]
MCF7	GI₅₀	0.005 1 Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28895394]
L1210	IC₅₀	0.03 1 Compound: Dolastatin 10	Compound was evaluated for antiproliferative activity against murine leukemia (L1210) cell lines. Compound was evaluated for antiproliferative activity against murine leukemia (L1210) cell lines.	[PMID: 9873636]
MCF7	IC₅₀	0.083 1 Compound: 4a	Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method	[PMID: 16124759]
L1210	IC₅₀	0.03 1 Compound: Dolastatin 10	Inhibitory activity against growth of L1210 cell line Inhibitory activity against growth of L1210 cell line	[PMID: 9554885]
NCI-H460	GI₅₀	0.229 1 Compound: 2	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28926240]
MCF7	IC₅₀	0.03 1 Compound: Dolastatin 10	Inhibitory activity against growth of MCF-7 cell line Inhibitory activity against growth of MCF-7 cell line	[PMID: 9554885]
HT-29	IC₅₀	0.018 1 Compound: 1	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay	[PMID: 39068862]
NCI-H460	GI₅₀	0.229 1 Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28895394]
HT-29	IC₅₀	0.06 1 Compound: 1	Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay	[PMID: 35072477]
NCI-H446	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H446 cells assessed as cell growth inhibition Anticancer activity against human NCI-H446 cells assessed as cell growth inhibition	[PMID: 35072477]
SF-268	GI₅₀	0.006 1 Compound: 2	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28926240]
HT-29	IC₅₀	0.06 1 Compound: Dolastatin 10	Inhibitory activity against growth of HT-29 cell line Inhibitory activity against growth of HT-29 cell line	[PMID: 9554885]
NCI-H510A	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H510A cells assessed as cell growth inhibition Anticancer activity against human NCI-H510A cells assessed as cell growth inhibition	[PMID: 35072477]
SF-268	GI₅₀	0.006 1 Compound: 1	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28895394]
NCI-H69	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H69 cells assessed as cell growth inhibition Anticancer activity against human NCI-H69 cells assessed as cell growth inhibition	[PMID: 35072477]
HT-29	IC₅₀	0.06 1 Compound: Dolastatin 10	Compound was evaluated for antiproliferative activity against human colon adenocarcinoma (HT-29) cell lines. Compound was evaluated for antiproliferative activity against human colon adenocarcinoma (HT-29) cell lines.	[PMID: 9873636]
KB	IC₅₀	0.041 1 Compound: synthetic 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
NCI-H82	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H82 cells assessed as cell growth inhibition Anticancer activity against human NCI-H82 cells assessed as cell growth inhibition	[PMID: 35072477]
KB	IC₅₀	0.052 1 Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
A498	GI₅₀	0.033 1 Compound: 1	Anticancer activity against human A498 cells assessed as growth inhibition Anticancer activity against human A498 cells assessed as growth inhibition	[PMID: 35072477]
KB	IC₅₀	0.041 1 Compound: synthetic 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
KB	IC₅₀	< 0.1 14 Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9748368]
KM-20L2	GI₅₀	0.006 1 Compound: 1	Anticancer activity against human KM-20L2 cells assessed as growth inhibition Anticancer activity against human KM-20L2 cells assessed as growth inhibition	[PMID: 35072477]
BXPC-3	GI₅₀	0.051 1 Compound: 1	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28895394]
BXPC-3	GI₅₀	0.051 1 Compound: 2	Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay Growth inhibition of human BxPC3 cells after 48 hrs by SRB assay	[PMID: 28926240]
KM-20L2	GI₅₀	0.01 1 Compound: 1	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28895394]
KB	IC₅₀	0.052 1 Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11473421]
KM-20L2	GI₅₀	0.01 1 Compound: 2	Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay Growth inhibition of human KM20L2 cells after 48 hrs by SRB assay	[PMID: 28926240]
HT-29	IC₅₀	0.06 1 Compound: 1	Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay	[PMID: 35072477]
L1210	IC₅₀	0.03 1 Compound: Dolastatin 10	Inhibitory activity against growth of L1210 cell line Inhibitory activity against growth of L1210 cell line	[PMID: 9554885]
L1210	IC₅₀	0.03 1 Compound: Dolastatin 10	Compound was evaluated for antiproliferative activity against murine leukemia (L1210) cell lines. Compound was evaluated for antiproliferative activity against murine leukemia (L1210) cell lines.	[PMID: 9873636]
HT-29	IC₅₀	0.06 1 Compound: Dolastatin 10	Compound was evaluated for antiproliferative activity against human colon adenocarcinoma (HT-29) cell lines. Compound was evaluated for antiproliferative activity against human colon adenocarcinoma (HT-29) cell lines.	[PMID: 9873636]
L1210	IC₅₀	0.9 1 Compound: 1	Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs	[PMID: 35072477]
HT-29	IC₅₀	0.06 1 Compound: Dolastatin 10	Inhibitory activity against growth of HT-29 cell line Inhibitory activity against growth of HT-29 cell line	[PMID: 9554885]
LoVo	IC₅₀	0.066 1 Compound: synthetic 1	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]
LoVo	IC₅₀	0.066 1 Compound: synthetic 1	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]
LoVo	IC₅₀	0.076 1 Compound: 1	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]
LoVo	IC₅₀	0.076 1 Compound: 1	Cytotoxicity against human LoVo cells Cytotoxicity against human LoVo cells	[PMID: 11473421]
MCF7	IC₅₀	0.083 1 Compound: 4a	Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method	[PMID: 16124759]
MCF7	GI₅₀	0.005 1 Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28895394]
NCI-H460	GI₅₀	0.229 1 Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28895394]
MCF7	GI₅₀	0.005 1 Compound: 2	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 28926240]
NCI-H460	GI₅₀	0.229 1 Compound: 2	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28926240]
MCF7	IC₅₀	0.03 1 Compound: Dolastatin 10	Inhibitory activity against growth of MCF-7 cell line Inhibitory activity against growth of MCF-7 cell line	[PMID: 9554885]
A10	EC₅₀	0.25 1 Compound: 1	Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence Antitumor activity against rat A10 cells assessed as loss of cellular microtubule after 18 hrs by indirect immunofluorescence	[PMID: 11473421]
MCF7	IC₅₀	0.083 1 Compound: 4a	Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method Growth inhibition of human MCF7 after 48 hrs by sulforhodamine B method	[PMID: 16124759]
HCT-116	IC₅₀	0.48 1 Compound: 1	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
NCI-H446	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H446 cells assessed as cell growth inhibition Anticancer activity against human NCI-H446 cells assessed as cell growth inhibition	[PMID: 35072477]
L1210	IC₅₀	0.9 1 Compound: 1	Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition measured after 24 hrs	[PMID: 35072477]
HCT-116	IC₅₀	24 1 Compound: 1	Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against oncogenic KRAS knockout human HCT116 cells expressing wild type KRAS assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
CA46	IC₅₀	30 1 Compound: Dolastatin 10	Cytotoxicity against human CA46 cell line Cytotoxicity against human CA46 cell line	[PMID: 16837194]
NCI-H460	GI₅₀	0.004 1 Compound: 1	Anticancer activity against human NCI-H460 cells assessed as growth inhibition Anticancer activity against human NCI-H460 cells assessed as growth inhibition	[PMID: 35072477]
NCI-H460	GI₅₀	0.229 1 Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28895394]
KB	IC₅₀	<0.1 14 Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9748368]
NCI-H460	GI₅₀	0.229 1 Compound: 2	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 28926240]
leukaemia cell line	ED₅₀	4.6*10^-5 6 Compound: 1	Cytotoxicity against human leukaemia cell line assessed as cell growth inhibition Cytotoxicity against human leukaemia cell line assessed as cell growth inhibition	[PMID: 35072477]
NCI-H510A	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H510A cells assessed as cell growth inhibition Anticancer activity against human NCI-H510A cells assessed as cell growth inhibition	[PMID: 35072477]
HCT-116	IC₅₀	65 1 Compound: 1	Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay Cytotoxicity against human HIF1alpha and HIF2alpha deficit HCT116 cells assessed as reduction in cell viability measured after 48 hrs by ATPlite 1step luminescence assay	[PMID: 27380142]
NCI-H69	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H69 cells assessed as cell growth inhibition Anticancer activity against human NCI-H69 cells assessed as cell growth inhibition	[PMID: 35072477]
P388	ED₅₀	0.1 14 Compound: Dolastatin10	Anticancer activity against lymphocytic leukemia P388 cells was determined Anticancer activity against lymphocytic leukemia P388 cells was determined	[PMID: 9871690]
NCI-H82	IC₅₀	0.032 1 Compound: 1	Anticancer activity against human NCI-H82 cells assessed as cell growth inhibition Anticancer activity against human NCI-H82 cells assessed as cell growth inhibition	[PMID: 35072477]
P388	ED₅₀	0.001 6 Compound: 1	Effect against cell growth of the P388 lymphocytic leukemia (PS system) Effect against cell growth of the P388 lymphocytic leukemia (PS system)	[PMID: 2258898]
OVCAR-3	GI₅₀	0.001 1 Compound: 1	Anticancer activity against human OVCAR-3 cells assessed as growth inhibition Anticancer activity against human OVCAR-3 cells assessed as growth inhibition	[PMID: 35072477]
P388	ED₅₀	0.001 6 Compound: 1	Effect against cell growth of the P388 lymphocytic leukemia (PS system) Effect against cell growth of the P388 lymphocytic leukemia (PS system)	[PMID: 2258898]
P388	ED₅₀	0.1 14 Compound: Dolastatin10	Anticancer activity against lymphocytic leukemia P388 cells was determined Anticancer activity against lymphocytic leukemia P388 cells was determined	[PMID: 9871690]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.01 1 Compound: 1	Cytotoxicity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition Cytotoxicity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition	[PMID: 35072477]
SF-268	GI₅₀	0.006 1 Compound: 1	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28895394]
SF-268	GI₅₀	0.006 1 Compound: 2	Growth inhibition of human SF268 cells after 48 hrs by SRB assay Growth inhibition of human SF268 cells after 48 hrs by SRB assay	[PMID: 28926240]
SF-295	GI₅₀	0.01 1 Compound: 1	Anticancer activity against human SF-295 cells assessed as growth inhibition Anticancer activity against human SF-295 cells assessed as growth inhibition	[PMID: 35072477]
SK-MEL-5	GI₅₀	0.009 1 Compound: 1	Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition	[PMID: 35072477]
leukaemia cell line	ED₅₀	4.6 x 10^-5 6 Compound: 1	Cytotoxicity against human leukaemia cell line assessed as cell growth inhibition Cytotoxicity against human leukaemia cell line assessed as cell growth inhibition	[PMID: 35072477]

体外実験

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI₅₀ values of 10^?5-10^?6 μg/mL (10^?2-10^?3 nM) against a similar minipanel of human cell lines^[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

785.09

分子式

C₄₂H₆₈N₆O₆S

CAS 番号

110417-88-4

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3

Structure Classification

Others

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
*The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (127.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2737 mL	6.3687 mL	12.7374 mL
5 mM	0.2547 mL	1.2737 mL	2.5475 mL
10 mM	0.1274 mL	0.6369 mL	1.2737 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.34%

Select Batch:

データシート (276 KB) SDS (393 KB)

COA (254 KB) RP-HPLC (216 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31. [Content Brief]

[2]. Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74(5):962-8. [Content Brief]

[3]. Brentuximab vedotin. Drugs R D. 2011;11(1):85-95. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2737 mL	6.3687 mL	12.7374 mL	31.8435 mL
	5 mM	0.2547 mL	1.2737 mL	2.5475 mL	6.3687 mL
	10 mM	0.1274 mL	0.6369 mL	1.2737 mL	3.1843 mL
	15 mM	0.0849 mL	0.4246 mL	0.8492 mL	2.1229 mL
	20 mM	0.0637 mL	0.3184 mL	0.6369 mL	1.5922 mL
	25 mM	0.0509 mL	0.2547 mL	0.5095 mL	1.2737 mL
	30 mM	0.0425 mL	0.2123 mL	0.4246 mL	1.0614 mL
	40 mM	0.0318 mL	0.1592 mL	0.3184 mL	0.7961 mL
	50 mM	0.0255 mL	0.1274 mL	0.2547 mL	0.6369 mL
	60 mM	0.0212 mL	0.1061 mL	0.2123 mL	0.5307 mL
	80 mM	0.0159 mL	0.0796 mL	0.1592 mL	0.3980 mL
	100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.3184 mL

Dolastatin 10 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dolastatin 10110417-88-4DLS 10 NSC 376128Dolastatin10Dolastatin-10DLS10DLS-10NSC376128NSC 376128NSC-376128Microtubule/TubulinADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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Dolastatin 10 (Synonyms: DLS 10; NSC 376128)

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Complete Stock Solution Preparation Table

Dolastatin 10 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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Dolastatin 10 (Synonyms: DLS 10; NSC 376128)

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Dolastatin 10 関連抗体

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•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

ADC Payload アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Dolastatin 10 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Dolastatin 10 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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