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Imatinib Mesylate

(Synonyms: STI571 Mesylate; CGP-57148B Mesylate)
127 Cited Publications
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Based on 127 publication(s) in Google Scholar

Imatinib Mesylate (STI571 Mesylate) is an orally active tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 220127-57-1
  • Formula: C30H35N7O4S
  • Molecular Weight:589.71
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Imatinib Mesylate Chemical Structure
    Imatinib Mesylate Chemical Structure
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
  • Experimental Validation Results for Imatinib Mesylate
CAS No.: 220127-57-1
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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WBCell Proliferation/Viability AssayIHC
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  • Imatinib Mesylate Chemical Structure
    Imatinib Mesylate Chemical Structure
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    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: Cell Chem Biol. 2018 Aug 16;25(8):996-1005.e4. [Abstract]

    Customer Validation
     Negligible increases in caspase-3 activity or PARP-1 cleavage is observed in PC-9 GR NSCLC cells treated with DMSO, single agent PAC-1 (5 mM), or Osimertinib (Osi). In cells treated with PAC-1+Osimertinib, dramatic increases in caspase-3 activity is observed as early as 36 hr post treatment.

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2018 Apr 24;9(31):22158-22183. [Abstract]

    Customer Validation
     Primary tumors are dissected at the end of experiment and subjected to immunohistochemistry. Representative images of primary tumor sections stained with anti-PCNA (proliferation), anti-cleaved caspase 3 (apoptosis), and anti-CD31 (angiogenesis).

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: PLoS One. 2017 Jun 1;12(6):e0178619. [Abstract]

    Customer Validation
     The protein expression of PDGF-A, PDGF-B, PDGF-C, and PDGF-D in hearts from mice treated with vehicle, Imatinib (IMA), ISO, IMA+ISO for one week is tested by Western blot.

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: Med Sci Monit. 2017 Aug 6:23:3808-3816. [Abstract]

    Customer Validation
     The kinase activity of c-Kit is enhanced in an animal model of cardiac fibrosis. The lysates of heart tissues from a mice model treated with vehicle, Imatinib (IMA), ISO, or Imatinib + ISO for one week are analyzed for phosphorylation level of p-c-Kit (Tyr719) and total protein level of c-Kit. The western blotting results from one mouse in each group and the statistical analysis of the western blotting bands are shown.

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 15;8(67):111110-111118. [Abstract]

    Customer Validation
     In cell EC50 determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells.

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: J Med Chem. 2016 Sep 22;59(18):8456-72. [Abstract]

    Customer Validation
     Effect of compounds 1 (Imatinib), 2 (Sunitinib), and 35 on cKIT mediated signaling pathways in GIST-T1 and GIST-5R cancer cell lines.

  • 1/16

    Imatinib Mesylate purchased from MedChemExpress. Usage Cited in: J Bioenerg Biomembr. 2012 Feb;44(1):155-61. [Abstract]

    Customer Validation
     Differences in sensitivity of PDR-mutants to 3-BP, Imatinib methanesulfonate, Daunorubicin and Rhodamine 6 G. Minimal medium (YNB) with sucrose.

  • Imatinib Mesylate