2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Tyrosine

L-チロシン  (Synonyms: L-Tyrosine; Tyrosine)

製品番号: HY-N0473 純度: 98.73%
COA 取扱説明書 Technical Support

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

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L-Tyrosine

L-チロシン 構造式

CAS 番号 : 60-18-4

容量 価格（税別） 在庫状況 数量
200 mg $66 在庫あり
500 mg $92 在庫あり
1 g $138 在庫あり
5 g $276 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 7 publication(s) in Google Scholar

Other Forms of L-Tyrosine:

L-チロシン 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

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  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外実験

L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1-4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0-4.0 mM) following treatment with L-Tyrosine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-チロシン 関連抗体
体内実験

The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

181.19

分子式

C9H11NO3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CC=C(C=C1)O)C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

1M HCl : 50 mg/mL (275.95 mM; Need ultrasonic)

0.1 M HCl : 25 mg/mL (137.98 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5190 mL 27.5952 mL 55.1904 mL
5 mM 1.1038 mL 5.5190 mL 11.0381 mL
10 mM 0.5519 mL 2.7595 mL 5.5190 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 40 mg/mL (220.76 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

  • Protocol 2

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 40 mg/mL (220.76 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.73%

COA (245 KB) RP-HPLC (258 KB) MS (205 KB) Elemental Analysis Report (104 KB)

取扱説明書 (2659 KB)
参考文献
キナーゼ実験
[1]

Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II–III and IV are evaluated[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
動物実験
[1]

The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M HCl / 1M HCl 1 mM 5.5190 mL 27.5952 mL 55.1904 mL 137.9760 mL
5 mM 1.1038 mL 5.5190 mL 11.0381 mL 27.5952 mL
10 mM 0.5519 mL 2.7595 mL 5.5190 mL 13.7976 mL
15 mM 0.3679 mL 1.8397 mL 3.6794 mL 9.1984 mL
20 mM 0.2760 mL 1.3798 mL 2.7595 mL 6.8988 mL
25 mM 0.2208 mL 1.1038 mL 2.2076 mL 5.5190 mL
30 mM 0.1840 mL 0.9198 mL 1.8397 mL 4.5992 mL
40 mM 0.1380 mL 0.6899 mL 1.3798 mL 3.4494 mL
50 mM 0.1104 mL 0.5519 mL 1.1038 mL 2.7595 mL
60 mM 0.0920 mL 0.4599 mL 0.9198 mL 2.2996 mL
80 mM 0.0690 mL 0.3449 mL 0.6899 mL 1.7247 mL
100 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3798 mL
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L-Tyrosine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Tyrosine60-18-4TyrosineEndogenous MetaboliteInhibitorinhibitorinhibit

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