1. Anti-infection
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. Bacterial
    DNA/RNA Synthesis
    Endogenous Metabolite
  3. 2-(Methylamino)-1H-purin-6(7H)-one

2-(Methylamino)-1H-purin-6(7H)-one  (Synonyms: N2-methylguanine)

Cat. No.: HY-101412 Purity: ≥98.0%
COA Handling Instructions

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

For research use only. We do not sell to patients.

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

CAS No. : 10030-78-1

Size Price Stock Quantity
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2-(Methylamino)-1H-purin-6(7H)-one

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

IC50 & Target

Human Endogenous Metabolite


In Vitro

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight






Structure Classification

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (6.06 mM; ultrasonic and warming and heat to 80°C)

DMSO : 1 mg/mL (6.06 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

THF : < 1 mg/mL (ultrasonic) (insoluble)

1M NaOH : < 1 mg/mL (ultrasonic;adjust pH to 12 with NaOH) (insoluble)

Acetone : < 1 mg/mL (ultrasonic) (insoluble)

0.1 M HCL : < 1 mg/mL (ultrasonic;adjust pH to 2 with HCl) (insoluble)

DMF : < 1 mg/mL (ultrasonic) (insoluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.5510 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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