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    Cell Cycle/DNA Damage
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    Endogenous Metabolite
  3. 2-(Methylamino)-1H-purin-6(7H)-one

2-(Methylamino)-1H-purin-6(7H)-one (Synonyms: N2-methylguanine)

Cat. No.: HY-101412 Purity: ≥98.0%
Handling Instructions

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

For research use only. We do not sell to patients.

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

2-(Methylamino)-1H-purin-6(7H)-one Chemical Structure

CAS No. : 10030-78-1

Size Price Stock Quantity
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

165.15

Formula

C₆H₇N₅O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (6.06 mM; ultrasonic and warming and heat to 80°C)

DMSO : 1 mg/mL (6.06 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

THF : < 1 mg/mL (ultrasonic) (insoluble)

1M NaOH : < 1 mg/mL (ultrasonic;adjust pH to 12 with NaOH) (insoluble)

Acetone : < 1 mg/mL (ultrasonic) (insoluble)

0.1 M HCL : < 1 mg/mL (ultrasonic;adjust pH to 2 with HCl) (insoluble)

DMF : < 1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.5510 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
2-(Methylamino)-1H-purin-6(7H)-one
Cat. No.:
HY-101412
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