2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Relebactam

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.

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CAS. Nr. : 1174018-99-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 29 publication(s) in Google Scholar

Other Forms of Relebactam:

Relebactam Related Antibodies

Top Publications Citing Use of Products

29 Publications Citing Use of MCE Relebactam

Microbiological Assay
Bio/Physico-chemical Assay

    Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2024 May 14:107206.  [Abstract]

    The MultiRapid ATB NP test. Column D shows the solution with imipenem–relebactam (IPR, 12/4 mg/L);. Reference strain Escherichia coli ATCC 25922 was inoculated in wells A1–F1; Positive control resistant to all the antibiotics was inoculated in wells A2–F2; First tested strain (resistant to CZA, MEV, and IPR) was inoculated in wells A3–F3; Second tested strain (resistant to CZA and FDC) was inoculated in wells A4–F4; and NaCl 0.85% was inoculated in wells A5–F5. Bacterial growth is shown by a colour change of the medium from red to yellow.

    Relebactam purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0160322.  [Abstract]

    Difference between whole cells and isolated PBPs fraction unbound. P. aeruginosa PAO1 cultures (whole cells) and PBP-containing membrane preparations (isolated) were incubated for 15, 30, and 60 min in the presence of relebactam (REL), and afterwards isolated PBPs labeled with 25 μM Boc-FL.

    Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669.  [Abstract]

    The MICs of seven β-lactams with relebactam 8 mg/L against M. abscessus.

    Relebactam purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669.  [Abstract]

    The MICs of seven β-lactams with relebactam 8 mg/L against M. massiliense.

    Relebactam purchased from MedChemExpress. Usage Cited in: Antibiotics (Basel). 2021 Nov 3;10(11):1341.

    Twenty-four-hour time–kill curves of aztreonam (ATM) and relebactam (REL), alone and in combination, on: C. amalonaticus N18; K. pneumoniae KL 12 SG; K. pneumoniae LC954/14.

    Alle Beta-lactamase Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

    • Biologische Aktivität

    • Reinheit & Dokumentation

    • Verweise

    • Kundenbewertung

    Beschreibung

    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity[1].

    In Vitro

    Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa[1].
    Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Relebactam Related Antibodies
    Klinische Studie
    Molekulargewicht

    348.38

    Formel

    C12H20N4O6S
    CAS. Nr.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)(O)=O
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 175 mg/mL (502.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (143.52 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8704 mL 14.3521 mL 28.7043 mL
    5 mM 0.5741 mL 2.8704 mL 5.7409 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (71.76 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Reinheit & Dokumentation

    Purity: 99.95%

    SDS (393 KB)

    COA (249 KB) HNMR (291 KB) RP-HPLC (185 KB) MS (232 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.8704 mL 14.3521 mL 28.7043 mL 71.7607 mL
    5 mM 0.5741 mL 2.8704 mL 5.7409 mL 14.3521 mL
    10 mM 0.2870 mL 1.4352 mL 2.8704 mL 7.1761 mL
    15 mM 0.1914 mL 0.9568 mL 1.9136 mL 4.7840 mL
    20 mM 0.1435 mL 0.7176 mL 1.4352 mL 3.5880 mL
    25 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8704 mL
    30 mM 0.0957 mL 0.4784 mL 0.9568 mL 2.3920 mL
    40 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7940 mL
    50 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
    60 mM 0.0478 mL 0.2392 mL 0.4784 mL 1.1960 mL
    80 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
    100 mM 0.0287 mL 0.1435 mL 0.2870 mL 0.7176 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Relebactam Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Relebactam1174018-99-5MK-7655MK7655MK 7655Beta-lactamaseBacterialβ-lactamaseImipenemEnterobacteriaceaeP. aeruginosaβ-lactamasesantibacterialInhibitorinhibitorinhibit

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