2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W014566
    4-Nitro-3-(trifluoromethyl)phenol 88-30-2 99.91%
    4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC50 values are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations.
    4-Nitro-3-(trifluoromethyl)phenol
  • HY-W015399
    4-Methylcinnamic acid 1866-39-3 99.49%
    4-Methylcinnamic acid is a cinnamic acid derivative with antifungal activity. 4-Methylcinnamic acid can overcome the tolerance of glutathione reductase mutants to 4-Methoxycinnamic acid (HY-N1387). When 4-Methylcinnamic acid is used in combination with traditional antifungal agents, it can reduce their minimum inhibitory concentrations. 4-Methylcinnamic acid can act as an intervention catalyst to enhance the efficacy of traditional antifungal agents and has application potential in targeting fungal cell wall disruption and controlling drug-resistant fungi.
    4-Methylcinnamic acid
  • HY-W017445
    Homogentisic acid lactone 2688-48-4 99.11%
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity.
    Homogentisic acid lactone
  • HY-W018143
    1-Methyl-4-nitroimidazole 3034-41-1 98%
    1-Methyl-4-nitroimidazole is an antibacterial agent. 1-Methyl-4-nitroimidazole is reduced by bacterial nitroreductases to form toxic derivatives, which cause DNA damage, inhibit bacterial nucleic acid synthesis, generate toxic superoxides through futile cycling of reduced radical anions, and induce bacterial cell death. 1-Methyl-4-nitroimidazole exhibits moderate in vitro activity against bacteria and fungal. 1-Methyl-4-nitroimidazole can be used in the research of skin infections, purulent infections and urinary tract infections.
    1-Methyl-4-nitroimidazole
  • HY-W018629
    Antibacterial agent 265 112811-72-0 99.59%
    Antibacterial agent 265 (Compound 2) is an antibacterial agent. Antibacterial agent 265 shows antibacterial activity against Staphylococcus Aureus, Micrococcus Luteus, Bacillus subtilis, gram-negative Escherichia coli, Pseudomonas aeruginosa and Flavobacterium devorans.
    Antibacterial agent 265
  • HY-W019617
    2-Ethylbenzimidazole 1848-84-6
    2-Ethylbenzimidazole is an anti-fungal agent. 2-Ethylbenzimidazole inhibits the growth of unicellular fungi and filamentous fungi. 2-Ethylbenzimidazole is applicable for the research of fungal infections.
    2-Ethylbenzimidazole
  • HY-W020111
    7-Chloro-4-(piperazin-1-yl)quinoline 837-52-5
    7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively.
    7-Chloro-4-(piperazin-1-yl)quinoline
  • HY-W029719
    [5-(2-Thienyl)-3-isoxazolyl]methanol 194491-44-6 99.88%
    [5-(2-Thienyl)-3-isoxazolyl]methanol (Compound D) is an AgrA-DNA binding inhibitor. [5-(2-Thienyl)-3-isoxazolyl]methanol can be used for S.aureus infection research.
    [5-(2-Thienyl)-3-isoxazolyl]methanol
  • HY-W047478
    3-Methylcarbazole 4630-20-0
    3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases.
    3-Methylcarbazole
  • HY-W048220
    (S)-2-Aminohex-5-enoic acid 90989-12-1 98%
    (S)-2-Aminohex-5-enoic acid is an enantiomerically pure non-proteinogenic α-amino acid (homoallylglycine) and synthetic precursor for (2S,5R)- and (2S,5S)-5-hydroxypipecolic acid. (S)-2-Aminohex-5-enoic acid can be used in research on bacterial and fungal infections.
    (S)-2-Aminohex-5-enoic acid
  • HY-W105741
    12-Bromododecanoic acid 73367-80-3 99.65%
    12-Bromododecanoic acid is a bromo fatty acid. 12-Bromododecanoic acid can be used in the synthesis of clickable forms of myristic acid. 12-Bromododecanoic acid inhibits HIV replication in CEM-SS T cells (EC50 = 38 µM).
    12-Bromododecanoic acid
  • HY-W109613
    Methyl dehydroabietate 1235-74-1 99.89%
    Methyl dehydroabietate is an orally active resin acid. Methyl dehydroabietate disrupts microbial cell walls and exhibits significant antibacterial activity. Methyl dehydroabietate induces the expression of PPARα in the liver and PPARγ in adipose tissue, and promotes adipocyte differentiation. Methyl dehydroabietate improves insulin resistance, reduces TNFα levels, and alleviates adipocyte hypertrophy and hepatic steatosis in obese mice. Methyl dehydroabietate can be used in research related to obesity, insulin resistance and hepatic steatosis.
    Methyl dehydroabietate
  • HY-W129233
    Dihydroartemisinin (mixture of α and β isomers) 131175-87-6 98.0%
    Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress.
    Dihydroartemisinin (mixture of α and β isomers)
  • HY-W139907
    1,2-Dimethylbenzimidazole 2876-08-6 98.0%
    1,2-Dimethylbenzimidazole is a benzimidazole derivative. 1,2-Dimethylbenzimidazole exhibits antiparasitic activity with an IC50 of 0.089 μM against G. duodenalis. 1,2-Dimethylbenzimidazole can also be used in the synthesis of other bioactive compounds, such as antitumor agents.
    1,2-Dimethylbenzimidazole
  • HY-W196368
    Thymohydroquinone 2217-60-9 99.91%
    Thymohydroquinone is a COX-2 inhibitor and anti-SARS-CoV-2 agent that induces cytotoxicity, antiproliferative effects and inhibits tumor growth. Thymohydroquinone cannot scavenge superoxide radicals via σ (hydrogen atom transfer) and π-π attacks with superoxide anions. Thymohydroquinone can be used in research related to squamous cell carcinoma, fibrosarcoma and coronavirus disease 2019 (SARS-CoV-2 infection).
    Thymohydroquinone
  • HY-W269306
    Bonaphthone 6954-48-9
    Bonaphthone is an antiviral agent with anti-DNA and -RNA viral activities.
    Bonaphthone
  • HY-W286805
    Perinaphthenone 548-39-0 99.92%
    Perinaphthenone has antifungal activity, with IC50s of 36.2 μM (at day 3), 13.3 μM (at day 3), and 39.0 μM (at 60 h) for Botrytis spp., Fusarium spp. and Botryodiplodia spp., respectively.
    Perinaphthenone
  • HY-W709856
    Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide 866602-52-0 98.54%
    Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations, which might be used for research of common cold and various upper respiratory infections.
    Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide
  • HY-W714076
    Ametoctradin 865318-97-4 99.20%
    Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
    Ametoctradin
  • HY-W728085
    CPPD-Q 68054-78-4 98.25%
    CPPD-Q is an antimicrobial agent and insecticide. CPPD-Q has an EC50 of 6.98 mg/L against Vibrio fischeri. At doses of 1 or 10 µg/mL, CPPD-Q exerts its insecticidal effect by inducing the production of reactive oxygen species (ROS) in the intestines of Caenorhabditis elegans.
    CPPD-Q
Cat. No. Product Name / Synonyms Application Reactivity