1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. Sirtuin
    Parasite
  3. 7-Chloro-4-(piperazin-1-yl)quinoline

7-Chloro-4-(piperazin-1-yl)quinoline 

Cat. No.: HY-W020111
Handling Instructions

7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively.

For research use only. We do not sell to patients.

7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure

7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure

CAS No. : 837-52-5

Size Price Stock Quantity
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
250 mg USD 140 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Description

7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].

Molecular Weight

247.72

Formula

C13H14ClN3

CAS No.
SMILES

ClC1=CC2=C(C(N3CCNCC3)=CC=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (67.29 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0368 mL 20.1841 mL 40.3682 mL
5 mM 0.8074 mL 4.0368 mL 8.0736 mL
10 mM 0.4037 mL 2.0184 mL 4.0368 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (6.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (6.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (6.74 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥95.0%

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Product Name:
7-Chloro-4-(piperazin-1-yl)quinoline
Cat. No.:
HY-W020111
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