Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives

  • Drug Dev Res. 2020 Nov;81(7):786-802. doi: 10.1002/ddr.21678.
Aida M Abd El-Sattar El-Azzouny  1 ,  Mohamed Nabil Aboul-Enein  1 ,  Mohamed Farouk Hamissa  1  2  3
Affiliations
  • 1. Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Giza, Egypt.
  • 2. Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, Czech Republic.
  • 3. Department of Biomolecular Spectroscopy, Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
PMID: 32385857 DOI: 10.1002/ddr.21678
Abstract

The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chemistry. It exhibited either alone or as hybrid with Other active pharmacophores diverse pharmacological profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, Anticancer, Sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.

Keywords
7-chloro-4-(piperazin-1-yl)quinoline; anti-HIV; anticancer; antidiabetic; antimalarial.
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