1-Methyl-4-nitroimidazole 

1-Methyl-4-nitroimidazole is an antibacterial agent. 1-Methyl-4-nitroimidazole is reduced by bacterial nitroreductases to form toxic derivatives, which cause DNA damage, inhibit bacterial nucleic acid synthesis, generate toxic superoxides through futile cycling of reduced radical anions, and induce bacterial cell death. 1-Methyl-4-nitroimidazole exhibits moderate in vitro activity against bacteria and fungal. 1-Methyl-4-nitroimidazole can be used in the research of skin infections, purulent infections and urinary tract infections^[1].

1-Methyl-4-nitroimidazole (1-methyl-4-nitro-1H-imidazole) (24-48 h) exhibits moderate activity against the tested Gram-positive bacteria, Gram-negative bacteria and fungal isolates, with a maximum inhibition zone of 18 mm against Staphylococcus aureus AB 188 and 18 mm against *Candida tropicalis*^[1].
1-Methyl-4-nitroimidazole (100-300 μg/mL; 24 h) inhibits the growth of tested Gram-positive bacteria, Gram-negative bacteria and fungal isolates, with an MIC range of 100-300 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

127.10

C₄H₅N₃O₂

3034-41-1

Solid

CN1C=NC([N+]([O-])=O)=C1

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Hafiz Abdullah Shahid, et al. Synthesis, crystal structure, structural characterization and in vitro antimicrobial activities of 1-methyl-4-nitro-1H-imidazole. Arabian Journal of Chemistry (2016)9668-675.