2. Infection

Infection

Infection

Related Products

PDF 70.44 MB

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P11600
    SGNLTKYWKKIWKPGIKKWIK 98%
    SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a KD value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and DNA binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections.
    SGNLTKYWKKIWKPGIKKWIK
  • HY-P11607
    CyLip-10 98%
    CyLip-10 is a microbial-derived cyclic-lipid antimicrobial peptide. CyLip-10 has broad-spectrum antimicrobial efficacy, low hemolytic activity, and excellent stability. CyLip-10 can disrupt membrane integrity, inhibit biofilm formation and induce membrane permeabilization and bacterial cell death. CyLip-10 reduces bacterial load, promotes wound healing, and alleviates inflammatory responses in a mouse Methicillin (HY-121544)-resistant Staphylococcus aureus skin wound infection model. CyLip-10 can be used for the bacterial infection.
    CyLip-10
  • HY-P11615
    FuK 98%
    FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds.
    FuK
  • HY-P11616
    WK2 98%
    WK2 is an antibacterial agent. WK2 reduces serum TNF-α production induced by Bacterial infection. WK2 reduces wound size and promotes tissue repair in a skin wound infection model. WK2 exerts anti-inflammatory effects in a pneumonia model. WK2 can be used for research on infectious diseases such as pneumonia caused by bacterial infection.
    WK2
  • HY-P11622
    Gramicidin S analogue 9 3106317-27-2
    Gramicidin S analogue 9 is a bactericidal agent that can be found as a cyclic peptide analogue. Gramicidin S analogue 9 disrupts bacterial cell membranes. Gramicidin S analogue 9 can be used for the research of methicillin-resistant staphylococcus aureus infection.
    Gramicidin S analogue 9
  • HY-P11630
    ZM-804 98%
    ZM-804 is a cationic α-helix antimicrobial peptide. ZM-804 targets bacterial cell membranes. ZM-804 demonstrates antimicrobial activity and prevents the infection of tomato plants by Pst DC3000. ZM-804 inhibits the growth of B. subtilis and E. coli (the same MICs of 41.10 μg/mL). ZM-804 exhibits low hemolytic activity.
    ZM-804
  • HY-P11640
    Vpr (1-14) 98%
    Vpr (1-14) is a viral protein R and acts as an accessory protein of HIV-1. Vpr (1-14) can binds to Cul4A-DDB1-DCAF1 E3 ligase complex and can be used as an E3 ligase-binding component in PROTACs. Vpr (1-14) can be used to synthesize PROTAC BRD4 Degrader-43 (HY-181164).
    Vpr (1-14)
  • HY-P11657
    GN-2 peptoid 1805781-73-0 98%
    GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections.
    GN-2 peptoid
  • HY-P11659
    B26 peptoid 98%
    B26 peptoid is a ptoid antibiotic. B26 peptoid exhibits excellent broad-spectrum activity and high selectivity toward a panel of Gram-positive and Gram-negative bacterial strains. B26 peptoid disrupts bacterial membranes and has bactericidal activity. B26 peptoid shows low propensity for bacterial drug resistance. B26 peptoid can be used for the research of bacterial infection.
    B26 peptoid
  • HY-P11676
    Soralimixin 1814918-91-6
    Soralimixin (BRII-693), a Polymyxin derivative, is a next-generation intravenous (IV)-administered synthetic macrocyclic peptide antibiotic. Soralimixin can be used for the study of infections caused by drug-resistant Gram-negative pathogens.
    Soralimixin
  • HY-P11713
    EBNA3B 399-408 179815-06-6 98%
    EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma.
    EBNA3B 399-408
  • HY-P11714
    EBNA3 246-254 457881-09-3 98%
    EBNA3 246-254 (RYSIFFDYM) is an EBV peptide. EBNA3 246-254 is submitted by HLA-A24. EBNA3 246-254 is amplified in vitro, followed by HLA multimer staining to measure EBV-specific CTLs. EBNA3 246-254 can be used for the research of lung cancer.
    EBNA3 246-254
  • HY-P11720
    M104 peptide 98%
    M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48. M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection.
    M104 peptide
  • HY-P11731
    Internal Transcribed Spacers (ITS) rRNA blocker
    Internal Transcribed Spacers (ITS) rRNA blocker is a peptide nucleic acid (PNA) blocker. Internal Transcribed Spacers (ITS) rRNA blocker binds and suppresses the amplification of the ITS2 rRNA region, a commonly overrepresented target sequence in fungal PCR. Internal Transcribed Spacers (ITS) rRNA blocker can be used in research involving PCR, sequencing, and gene detection.
    Internal Transcribed Spacers (ITS) rRNA blocker
  • HY-P11732
    acpP PNA
    acpP PNA is a 10-mer peptide nucleic acid targeting the bacterial essential gene acpP. acpP PNA can inhibit bacterial growth and reduce the level of target transcripts, and still retains activity with double terminal mismatches. acpP PNA may also cause off-target effects.
    acpP PNA
  • HY-P11733
    (KFF)3K-acpP
    (KFF)3K-acpP is an antibacterial agent conjugating of cell penetrating peptide (KFF)3K (HY-P10556) and acpP
    peptide nucleic acid. (KFF)3K-acpP binds to the translation start site region of acpP mRNA, sterically blocking ribosome binding and inhibiting translation of the acyl carrier protein. (KFF)3K-acpP induces bacterial envelope stress response pathways, and triggers depletion of outer membrane protein F (ompF) transcript. (KFF)3K-acpP can be used for the research of infections.
    (KFF)3K-acpP
  • HY-P11767
    NCR247 1372669-36-7 98%
    NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and heme chelator. NCR247 induces iron starvation responses in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity. NCR247 can be used in research related to periodontal disease and toxoplasmosis.
    NCR247
  • HY-P11772
    LBP-14 324030-22-0
    LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis.
    LBP-14
  • HY-P11783
    Surfactin C2 86711-55-9 98%
    Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers.
    Surfactin C2
  • HY-P11790
    EPEA tag peptide 1350920-46-5 98%
    EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaPEPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems.
    EPEA tag peptide
Cat. No. Product Name / Synonyms Application Reactivity