LBP-14 

LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis^[1].

LBP-14 (50 μM; 1 h preincubation, 4 h cell incubation) moderately inhibits LPS-induced TNF-α production in human buffy coat-derived PBMC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1765.07

C₈₂H₁₂₉N₂₇O₁₇

324030-22-0

Arg-Val-Gln-Gly-Arg-Trp-Lys-Val-Arg-Ala-Ser-Phe-Phe-Lys

RVQGRWKVRASFFK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pristovsek P, et al. Structure of a synthetic fragment of the lipopolysaccharide (LPS) binding protein when bound to LPS and design of a peptidic LPS inhibitor. J Med Chem. 2005;48(24):7911-7914.