2. Anti-infection
  3. Bacterial
  4. FuK

FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

FuK

FuK Chemical Structure

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FuK Related Antibodies

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Description

FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds[1].

In Vivo

FuK (5-10 mg/kg; i.p.; 4 and 12 hours post-infection) dose-dependently inhibits K. pneumoniae-induced pulmonary infection in BALB/c mice, reduces bacterial load and decreases inflammatory cell infiltration[1].
FuK (5-10 mg/kg; local administration; at 4, 12, and 24 hours post-infection) effectively treats MRSA-induced skin wound infections in BALB/c mice, promotes wound healing, and reduces bacterial load and inflammatory cell infiltration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 6−8 weeks old, 18−20 g) challenged with nebulized K. pneumoniae suspension[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; at 4 and 12 h post-infection
Result: Reduced K. pneumoniae lung burden to 5.32 × 105 CFU/mg (5 mg/kg dose) and 3.71 × 105 CFU/mg (10 mg/kg dose).
Caused slight alveolar dilation and reduced inflammatory cell infiltration, with enhanced therapeutic effects at higher doses.
Molecular Weight

1560.62

Formula

C72H97F12N15O10
Sequence

Gly-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-Ile-NH2
Sequence Shortening

G-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-I-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FuK Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FuKBacterialKlebsiella pneumoniaemethicillin-resistant S. aureusbiofilmBALB/c miceEscherichia colibacterial cytoplasmic membraneStaphylococcus aureusGram-negative bacteriabacterial outer membraneGram-positive bacteriaInhibitorinhibitorinhibit

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