2. Anti-infection
  3. Bacterial
  4. GN-2 peptoid

GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

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GN-2 peptoid

GN-2 peptoid Chemical Structure

CAS No. : 1805781-73-0

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GN-2 peptoid Related Antibodies

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Description

GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections[1].

In Vitro

GN-2 peptoid exhibits a MIC of 3.13 μg/mL against both Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (PAO1), and a MIC of 6.25 μg/mL against Escherichia coli. It possesses moderate antibacterial activity (SR=4-32) and shows no hemolytic activity (>128 μg/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GN-2 peptoid Related Antibodies

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: Hela WT cell
Concentration: 47 μg/mL
Incubation Time: /
Result: Showed cytotoxicity against human cells.
Molecular Weight

1443.82

Formula

C78H110N18O9
CAS No.
Sequence

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
Sequence Shortening

{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GN-2 peptoid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GN-2 peptoid1805781-73-0BacterialStaphylococcus aureusHeLa cellsGram-negativeEscherichia colimammalian cellsPseudomonas aeruginosahuman red blood cellshuman blood plasmaGram-positivebacterial infectionsInhibitorinhibitorinhibit

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