GN-2 peptoid
GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections.
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- CAS. Nr.: 1805781-73-0
- Formel: C78H110N18O9
- Molecular Weight:1443.82
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
In Vitro
GN-2 peptoid exhibits a MIC of 3.13 μg/mL against both Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (PAO1), and a MIC of 6.25 μg/mL against Escherichia coli. It possesses moderate antibacterial activity (SR=4-32) and shows no hemolytic activity (>128 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela WT cell
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Concentration:47 μg/mL
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Incubation Time:/
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Result:Showed cytotoxicity against human cells.
Chemical Information
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CAS. Nr. 1805781-73-0
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Molecular Weight 1443.82
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Formel C78H110N18O9
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Sequence
{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
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Sequence Shortening
{Nlys}-{Ntrp}-{Nlys}-{Nlys}-{Ntrp}-{Ntrp}-{Nlys}-{Ntrp}-{Nile}-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)