2. Anti-infection
  3. Bacterial
  4. CyLip-10

CyLip-10 is a microbial-derived cyclic-lipid antimicrobial peptide. CyLip-10 has broad-spectrum antimicrobial efficacy, low hemolytic activity, and excellent stability. CyLip-10 can disrupt membrane integrity, inhibit biofilm formation and induce membrane permeabilization and bacterial cell death. CyLip-10 reduces bacterial load, promotes wound healing, and alleviates inflammatory responses in a mouse Methicillin (HY-121544)-resistant Staphylococcus aureus skin wound infection model. CyLip-10 can be used for the bacterial infection.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CyLip-10

CyLip-10 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CyLip-10 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CyLip-10 is a microbial-derived cyclic-lipid antimicrobial peptide. CyLip-10 has broad-spectrum antimicrobial efficacy, low hemolytic activity, and excellent stability. CyLip-10 can disrupt membrane integrity, inhibit biofilm formation and induce membrane permeabilization and bacterial cell death. CyLip-10 reduces bacterial load, promotes wound healing, and alleviates inflammatory responses in a mouse Methicillin (HY-121544)-resistant Staphylococcus aureus skin wound infection model. CyLip-10 can be used for the bacterial infection[1].

In Vitro

CyLip-10 (18-24 h) exhibits broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacterial strains (including S. aureus ATCC 25923, B. subtilis ATCC 23857, E. coli ATCC 25922, K. pneumoniae ATCC 700603, and P. aeruginosa ATCC 27853) with a GMall (the
geometric mean of the MICs) of 7.34 μM[1].
CyLip-10 (1 h) shows low hemolytic toxicity against mouse red blood cells with an HC10 value of >256 μM[1].
CyLip-10 (1 h) has low cytotoxicity against HK-2 cells with a CC50 value of 210 μM[1].
CyLip-10 exhibits good serum stability in mouse serum with a half-life exceeding 48 h[1].
CyLip-10 maintains complete antimicrobial activity against S. aureus and E. coli after 6 h incubation with 2000 μg/mL of trypsin or chymotrypsin[1].
CyLip-10 (8-32 μM; 2-24 h) rapidly kills S. aureus and E. coli and inhibits the formation of biofilms[1].
CyLip-10 has a low propensity to induce resistance in S. aureus and P. aeruginosa over 20 passages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CyLip-10 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human kidney proximal tubular epithelial cells (HK-2)
Concentration: up to 128 μM
Incubation Time: 1 h
Result: Maintained a cell survival rate exceeding 50% even at the highest concentration of 128 μM.
Achieved a CC50 value of 210 μM.
In Vivo

CyLip-10 (2 mg/mL; topical; six doses at 1-hour intervals) effectively reduces S. aureus MRSA bacterial load in skin wounds, decreases inflammation, and promotes wound healing in MRSA-infected mice[1].
CyLip-10 (30-100 mg/kg; i.p.; single dose) has lower in vivo toxicity with an LD50 of 49.40 mg/kg in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/C (male, 6−8 weeks old, 20±2 g, MRSA-induced skin wound infection model)[1]
Dosage: 2 mg/mL
Administration: Topical; six doses at 1-hour intervals
Result: Significantly reduced MRSA bacterial load in wounds compared to the model group.
Reduced serum TNF-α levels.
Produced wound areas smaller than the model group by day 4 and nearly healed by day 8.
Improved skin tissue structure with distinct epidermis and dermis layers, less inflammatory cell infiltration, and basically normal cell morphology.
Molecular Weight

1358.67

Formula

C67H107N17O13
Sequence

C8-{Dab}-{Dab}-{D-Tyr}-Lys-{Dab}-{Dab}-Trp-{D-Leu}-{D-Leu}-Glu (Lactam bridge: Lys4-Glu10)
Sequence Shortening

C8-{Dab}-{Dab}-{D-Tyr}-K-{Dab}-{Dab}-W-{D-Leu}-{D-Leu}-E (Lactam bridge: Lys4-Glu10)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CyLip-10 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CyLip-10CyLip10CyLip 10BacterialP. aeruginosaE. coliHK-2 cellsStaphylococcus aureusmethicillin-resistant Staphylococcus aureusGram-positive bacteriaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CyLip-10
Cat. No.:
HY-P11607
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.