SGNLTKYWKKIWKPGIKKWIK
SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a KD value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and DNA binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections.
For research use only. We do not sell to patients.
- Formula: C128H200N32O26
- Molecular Weight:2603.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IL-6 |
IL-1β |
SGNLTKYWKKIWKPGIKKWIK (2-128 μM; 12-18 h) potently inhibits the growth of Escherichia coli K88, with an MIC of 2 μM[1].
SGNLTKYWKKIWKPGIKKWIK (2 μM; 1 h) disrupts the membrane integrity of Escherichia coli K88, increases outer/inner membrane permeability, depolarizes the membrane[1].
SGNLTKYWKKIWKPGIKKWIK (1-64 μM; 2 h) induces reactive oxygen species production in Escherichia coli K88[1].
SGNLTKYWKKIWKPGIKKWIK (0-256 μM; 40 min) binds to the genomic DNA of Escherichia coli K88 and inhibits DNA migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (female, 6 weeks old, 20.00 ± 2 g, challenged with Escherichia coli K88 suspension)[1]
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Dosage:20 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced bacterial loads in liver, kidney, spleen, and lung.
Alleviated tissue damage (vacuolar degeneration of hepatocytes, renal tubular epithelial cell edema, granulocyte infiltration in spleen and lungs).
Reduced serum levels of proinflammatory cytokines (IL-6, IL-1β, TNF-α) and HMGB1.
Chemical Information
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Molecular Weight 2603.16
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Formula C128H200N32O26
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Sequence
Ser-Gly-Asn-Leu-Thr-Lys-Tyr-Trp-Lys-Lys-Ile-Trp-Lys-Pro-Gly-Ile-Lys-Lys-Trp-Ile-Lys
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Sequence Shortening
SGNLTKYWKKIWKPGIKKWIK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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