2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Cell Cycle/DNA Damage
  3. Bacterial Reactive Oxygen Species (ROS) Interleukin Related DNA/RNA Synthesis
  4. SGNLTKYWKKIWKPGIKKWIK

SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a KD value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and DNA binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SGNLTKYWKKIWKPGIKKWIK

SGNLTKYWKKIWKPGIKKWIK Chemical Structure

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SGNLTKYWKKIWKPGIKKWIK Related Antibodies

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Description

SGNLTKYWKKIWKPGIKKWIK is a thymidylate kinase (TMK)-targeting antimicrobial peptide with a KD value of 4.721 μM. SGNLTKYWKKIWKPGIKKWIK exerts antimicrobial effects through multiple mechanisms, including membrane disruption, induction of ROS, and DNA binding. SGNLTKYWKKIWKPGIKKWIK shows remarkable activity against Gram-negative bacteria, possesses good biocompatibility, and rarely induces drug resistance. SGNLTKYWKKIWKPGIKKWIK can be used for research on Gram-negative bacterial infections[1].

IC50 & Target[1]

IL-6

 

IL-1β

 

In Vitro

SGNLTKYWKKIWKPGIKKWIK (2-128 μM; 12-18 h) potently inhibits the growth of Escherichia coli K88, with an MIC of 2 μM[1].
SGNLTKYWKKIWKPGIKKWIK (2 μM; 1 h) disrupts the membrane integrity of Escherichia coli K88, increases outer/inner membrane permeability, depolarizes the membrane[1].
SGNLTKYWKKIWKPGIKKWIK (1-64 μM; 2 h) induces reactive oxygen species production in Escherichia coli K88[1].
SGNLTKYWKKIWKPGIKKWIK (0-256 μM; 40 min) binds to the genomic DNA of Escherichia coli K88 and inhibits DNA migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGNLTKYWKKIWKPGIKKWIK Related Antibodies
In Vivo

SGNLTKYWKKIWKPGIKKWIK (20 mg/kg; i.p.; single dose) effectively clears pathogenic bacteria in vital organs, suppresses inflammatory factor production, and reduces organ damage in a mouse peritonitis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (female, 6 weeks old, 20.00 ± 2 g, challenged with Escherichia coli K88 suspension)[1]
Dosage: 20 mg/kg
Administration: i.p.; single dose
Result: Significantly reduced bacterial loads in liver, kidney, spleen, and lung.
Alleviated tissue damage (vacuolar degeneration of hepatocytes, renal tubular epithelial cell edema, granulocyte infiltration in spleen and lungs).
Reduced serum levels of proinflammatory cytokines (IL-6, IL-1β, TNF-α) and HMGB1.
Molecular Weight

2603.16

Formula

C128H200N32O26
Sequence

Ser-Gly-Asn-Leu-Thr-Lys-Tyr-Trp-Lys-Lys-Ile-Trp-Lys-Pro-Gly-Ile-Lys-Lys-Trp-Ile-Lys
Sequence Shortening

SGNLTKYWKKIWKPGIKKWIK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGNLTKYWKKIWKPGIKKWIK Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGNLTKYWKKIWKPGIKKWIKBacterialReactive Oxygen Species (ROS)Interleukin RelatedDNA/RNA SynthesisILROSEscherichia coli (K88)Gram-negative bacteriaRAW 264.7mouse peritonitis modelInhibitorinhibitorinhibit

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