2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. WK2

WK2 is an antibacterial agent. WK2 reduces serum TNF-α production induced by Bacterial infection. WK2 reduces wound size and promotes tissue repair in a skin wound infection model. WK2 exerts anti-inflammatory effects in a pneumonia model. WK2 can be used for research on infectious diseases such as pneumonia caused by bacterial infection.

For research use only. We do not sell to patients.

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WK2

WK2 Chemical Structure

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WK2 Related Antibodies

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Description

WK2 is an antibacterial agent. WK2 reduces serum TNF-α production induced by Bacterial infection. WK2 reduces wound size and promotes tissue repair in a skin wound infection model. WK2 exerts anti-inflammatory effects in a pneumonia model. WK2 can be used for research on infectious diseases such as pneumonia caused by bacterial infection[1][2].

In Vitro

WK2 binds LPS (HY-D1056) with high affinity, and when the concentration of LPS exceeds 32 μg/mL, it causes a decrease in bactericidal activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WK2 Related Antibodies
In Vivo

WK2 (5 mg/kg; i.p.; 6-36 h post-infection) exhibits significant anti-inflammatory effects in a mouse Klebsiella pneumoniae pneumonia model, reduces pulmonary bacterial loads, and alleviates histopathological signs of infection[2].
WK2 (2 mg/kg; topical administration; via 10 μL saline drops; 6-36 h post-infection) exhibits antibacterial activity in a mouse skin wound model infected with MRSA, reduces bacterial load, and promotes complete wound healing as well as regeneration of normal skin structure[2].
WK2 (15 mg/kg; i.p.; 30 min post-LPS injection) exhibits selective anti-inflammatory activity in a mouse model of LPS-induced systemic inflammation and reduces plasma TNF-α levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, intratracheal Klebsiella pneumoniae infection (50μL, 1×109 CFU/mL))[2]
Dosage: 5 mg/kg
Administration: i.p.; at 6, 12, 24, 30, and 36 h post-infection
Result: Reduced lung Klebsiella pneumoniae counts to 4.1 × 105 CFU/mg, compared to 2.67 × 106 CFU/mg in untreated infected mice.\nAlleviated inflammatory cell infiltration and promoted alveolar expansion, with less inflammation.
Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, dorsal wound methicillin-resistant Staphylococcus aureus infection (10 μL, 1 × 107 CFU/mL) )[2]
Dosage: 2 mg/kg
Administration: topical; via 10 μL saline drops; at 6, 12, 24, 30, and 36 h post-infection
Result: Exhibited significant antibacterial activity.
Demonstrated significant anti-MRSA activity, effectively preventing wound ulceration, gradually promoting wound healing, and causing the wound area to gradually decrease over time.
Improved the pathological changes in MRSA-infected mice, including wound thickening, inflammatory cell infiltration, and reduction of sebaceous glands and hair follicles.
Animal Model: BALB/c mice (male, 6-8 weeks old, 18-20 g, LPS (10 mg/kg,) i.p.)[2]
Dosage: 15 mg/kg
Administration: i.p.; 30 min post-LPS injection
Result: Reduced TNF-α levels induced by LPS.
Molecular Weight

1444.77

Formula

C76H105N19O10
Sequence

Gly-Trp-Trp-Lys-Lys-Trp-Trp-Lys-Lys-Ile-NH2
Sequence Shortening

GWWKKWWKKI-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WK2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WK2WK 2WK-2BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRKlebsiella pneumoniaemethicillin-resistant Staphylococcus aureusLPSpneumoniaskin wound infectionBALB/c miceInhibitorinhibitorinhibit

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