2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7885
    (25R)-Spirost-4-ene-3,12-dione 6875-60-1 99.61%
    (25R)-Spirost-4-ene-3,12-dione ((-)-(25R)-Spirost-4-ene-3,12-dione) is a natural product that has an inhibitory effect on neutrophil superoxide anion production and histamine release from mast cells.
    (25R)-Spirost-4-ene-3,12-dione
  • HY-N7933
    Tetracosane 646-31-1 98.0%
    Tetracosane (ALKANE C24) is a natural product that can be found in Acrostichum aureum. Tetracosane hows cytotoxicity and induces Apoptosis. Tetracosane has the potential for the research of peptic ulcer.
    Tetracosane
  • HY-N7992
    Myricetin-3-O-rutinoside 41093-68-9
    Myricetin-3-O-rutinoside is a Myricetin (HY-15097) derivative that can be found in the needles of Picea abies (Norway spruce). Myricetin-3-O-rutinoside exhibits certain anti-inflammatory activity.
    Myricetin-3-O-rutinoside
  • HY-N7993
    Manghaslin 55696-57-6 98.56%
    Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC50 of 94.92 μM.
    Manghaslin
  • HY-N8593
    Undecane 1120-21-4 99.66%
    Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.
    Undecane
  • HY-P5470
    LMP2A (426-434) 152274-91-4
    LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A*02 subtypes (A*02:01, A*02:03, A*02:06 and A*02:07). LMP2A (426-434) can induce a strong IFN-γ secretion response, stimulating the production of a high proportion of CD8+ IFN-γ+ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) .
    LMP2A (426-434)
  • HY-111927
    Pilloin 32174-62-2 98.98%
    Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.
    Pilloin
  • HY-119546
    Pinolenic acid 16833-54-8 99.80%
    Pinolenic acid (PNLA) is a polyunsaturated fatty acid that can be isolated from Pinus orientalis and Pinus pinaster seed oil. Pinolenic acid has anti-inflammatory and lipid-lowering activities.
    Pinolenic acid
  • HY-119594
    Melarsoprol 494-79-1 98.0%
    Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier.
    Melarsoprol
  • HY-122153
    VSN-16 863713-78-4 99.31%
    VSN-16 is a cannabinoid receptor agonist with vasodilatory activity. VSN-16 can be used for the study of multiple sclerosis.
    VSN-16
  • HY-14655R
    Sulfasalazine (Standard) 599-79-1 99.86%
    Sulfasalazine (Standard) is the analytical standard of Sulfasalazine. This product is intended for research and analytical applications. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.
    Sulfasalazine (Standard)
  • HY-147517
    Keap1-Nrf2-IN-9 2769963-24-6 98.52%
    Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells.
    Keap1-Nrf2-IN-9
  • HY-15027R
    5-Aminosalicylic Acid (Standard) 89-57-6 99.54%
    5-Aminosalicylic Acid (Standard) is the analytical standard of 5-Aminosalicylic Acid. This product is intended for research and analytical applications. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
    5-Aminosalicylic Acid (Standard)
  • HY-15315R
    Baricitinib (Standard) 1187594-09-7 99.86%
    Baricitinib (Standard) is the analytical standard of Baricitinib. This product is intended for research and analytical applications. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
    Baricitinib (Standard)
  • HY-154840
    4-Thiouridine 5′-triphosphate tetralithium 20188-72-1
    4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium (Compound 15) is a UTP analog and potent P2Y2 and P2Y4 agonist with EC50 values of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetrasodium can be used in cross-linking experiments and transcriptional complex labeling studies.
    4-Thiouridine 5′-triphosphate tetralithium
  • HY-156060
    NCI126224 65974-52-9 99.88%
    NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases.
    NCI126224
  • HY-158110
    Phenylcapsaicin 848127-67-3 99.77%
    Phenylcapsaicin is an analogue of Capsaicin (HY-10448). Phenylcapsaicin is a TRPV1 receptor activator. Phenylcapsaicin enhances fat oxidation during aerobic exercise.
    Phenylcapsaicin
  • HY-164756
    PKCTheta-IN-2 1810742-60-9 99.49%
    PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC50 of 682 nM).
    PKCTheta-IN-2
  • HY-165131
    Δ7-Avenasterol 7212-91-1
    Δ7-Avenasterol (Delta-7-avenasterol) is a phytosterol that binds to prostaglandin E2 receptor (prostaglandin E2 receptor) and cyclooxygenase-2 (COX-2). Δ7-Avenasterol is applicable to research related to gastric ulcer, anti-inflammation and antioxidation.
    Δ7-Avenasterol
  • HY-17363R
    Dimethyl fumarate (Standard) 624-49-7 99.85%
    Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.
    Dimethyl fumarate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity