LMP2A (426-434)
Based on 1 Customer Validation
LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A*02 subtypes (A*02:01, A*02:03, A*02:06 and A*02:07). LMP2A (426-434) can induce a strong IFN-γ secretion response, stimulating the production of a high proportion of CD8+ IFN-γ+ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) .
For research use only. We do not sell to patients.
- Purity: 96.09%
- CAS No.: 152274-91-4
- Formula: C39H71N9O11S2
- Molecular Weight:906.16
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
LMP2A (426-434) (20 μg/mL, 24 h) induces IFN-γ secreting cells at a frequency of 80.6 SFC/5×10⁴ CD8+ T cells[1].
LMP2A (426-434) (20 μg/mL, 2 weeks) stimulation significantly increased the proportion of CD8+IFN-γ+ cells[1].
LMP2A (426-434) (20 μg/mL, 4 h)-specific CTLs effectively kills peptide-pulsed T2 cells and 293T-LMP2A cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 152274-91-4
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Appearance Solid
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Molecular Weight 906.16
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Formula C39H71N9O11S2
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Color White to off-white
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Sequence
Cys-Leu-Gly-Gly-Leu-Leu-Thr-Met-Val
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Sequence Shortening
CLGGLLTMV
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (110.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang B, et al. Computational prediction and identification of Epstein-Barr virus latent membrane protein 2A antigen-specific CD8+ T-cell epitopes. Cell Mol Immunol. 2009 Apr;6(2):97-103. [Content Brief]
[2]. Lai J, et al. TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants. Sci Rep. 2017 Aug 30;7(1):9923. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1036 mL | 5.5178 mL | 11.0356 mL | 27.5889 mL |
| 5 mM | 0.2207 mL | 1.1036 mL | 2.2071 mL | 5.5178 mL | |
| 10 mM | 0.1104 mL | 0.5518 mL | 1.1036 mL | 2.7589 mL | |
| 15 mM | 0.0736 mL | 0.3679 mL | 0.7357 mL | 1.8393 mL | |
| 20 mM | 0.0552 mL | 0.2759 mL | 0.5518 mL | 1.3794 mL | |
| 25 mM | 0.0441 mL | 0.2207 mL | 0.4414 mL | 1.1036 mL | |
| 30 mM | 0.0368 mL | 0.1839 mL | 0.3679 mL | 0.9196 mL | |
| 40 mM | 0.0276 mL | 0.1379 mL | 0.2759 mL | 0.6897 mL | |
| 50 mM | 0.0221 mL | 0.1104 mL | 0.2207 mL | 0.5518 mL | |
| 60 mM | 0.0184 mL | 0.0920 mL | 0.1839 mL | 0.4598 mL | |
| 80 mM | 0.0138 mL | 0.0690 mL | 0.1379 mL | 0.3449 mL | |
| 100 mM | 0.0110 mL | 0.0552 mL | 0.1104 mL | 0.2759 mL |
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