152274-91-4
Chemical Structure
LMP2A (426-434)
- CAS. Nr.: 152274-91-4
- Formula:C39H71N9O11S2
- Molecular Weight:906.16
InChIKey: DGAJITDEHPNIPR-BXCYYTRQSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(NCC(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Biological Activity: LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A*02 subtypes (A*02:01, A*02:03, A*02:06 and A*02:07). LMP2A (426-434) can induce a strong IFN-γ secretion response, stimulating the production of a high proportion of CD8+ IFN-γ+ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) [1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
LMP2A (426-434) | 96.09% | LMP2A (426-434) is a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). LMP2A (426-434) can trigger an immune response in individuals expressing different HLA-A*02 subtypes (A*02:01, A*02:03, A*02:06 and A*02:07). LMP2A (426-434) can induce a strong IFN-γ secretion response, stimulating the production of a high proportion of CD8+ IFN-γ+ T cells. LMP2A (426-434) induces specific CTLs to effectively kill target cells expressing LMP2A. LMP2A (426-434) can be used to study EBV-related malignant tumors (such as Hodgkin's disease and nasopharyngeal carcinoma) . | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.84
HY-P5475BMLF1 (280–288) -
Similarity Score 0.77
HY-P1895β-Amyloid (33-40) -
Similarity Score 0.76
HY-P11426gp100 (17-25) -
Similarity Score 0.76
HY-P10507MART-1 nonamer antigen -
Similarity Score 0.75
HY-P5540Oximbomotide -
Similarity Score 0.75
HY-P4115CooP -
Similarity Score 0.74
HY-106187MART-1 (27-35) (human) -
Similarity Score 0.74
HY-P5471Melan-A/MART-1 analog -
Similarity Score 0.74
HY-P4914Sex Pheromone Inhibitor iPD1 -
Explore the MedChemAI to find more analogs
References
- [1]. Wang B, et al. Computational prediction and identification of Epstein-Barr virus latent membrane protein 2A antigen-specific CD8+ T-cell epitopes. Cell Mol Immunol. 2009 Apr;6(2):97-103. [Content Brief]
- [2]. Lai J, et al. TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants. Sci Rep. 2017 Aug 30;7(1):9923. [Content Brief]
