4-Thiouridine 5′-triphosphate tetralithium
Based on 1 Customer Validation
4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium (Compound 15) is a UTP analog and potent P2Y2 and P2Y4 agonist with EC50 values of 35 and 350 nM for hP2Y2 and hP2Y4, respectively. 4-Thiouridine 5′-triphosphate tetrasodium can be used in cross-linking experiments and transcriptional complex labeling studies.
For research use only. We do not sell to patients.
- Purity: 87.53%
- CAS No.: 20188-72-1
- Formula: C9H11Li4N2O14P3S
- Molecular Weight:523.94
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2Y Receptor Isoforms
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Biological Activity
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P2Y2 Receptor 35 nM (EC50) |
P2Y4 Receptor 350 nM (EC50) |
4-Thiouridine 5′-triphosphate tetrasodium is a potent P2Y2 and P2Y4 receptor agonist, with EC50s of 35 and 350 nM for hP2Y2 and hP2Y4, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 20188-72-1
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Appearance Solid
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Molecular Weight 523.94
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Formula C9H11Li4N2O14P3S
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Color Light yellow to yellow
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=S)=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
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Synonyms
4-Thio-UTP tetralithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jacobson KA, et, al. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol. 2006 Feb 14;71(4):540-9. [Content Brief]
[2]. Bartholomew B, et, al. RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes. J Biol Chem. 1986 Oct 25;261(30):14226-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Thiouridine 5′-triphosphate tetralithium Related Classifications
HY-154840 Related Classifications
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