2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W415753
    Alaptide 90058-29-0 98%
    Alaptide, a spirocyclic synthetic dipeptide and a derivative of melanocyte-stimulating hormone release-inhibiting factor (MIF), is a transdermal permeation modifier. Alaptide loaded on nanofibrous membranes accelerates the healing of skin incisions, particularly the healing of skin burns. Alaptide is a nootropic agent, that influences the dopaminergic system and increases homovanillic acid level in the striatum of rat models. Alaptide can be used for wound healing with large damaged areas and neurological diseases research.
    Alaptide
  • HY-W420454
    Danshenspiroketallactone 100414-80-0 98%
    Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity.
    Danshenspiroketallactone
  • HY-W424539
    Prednisolone sodium succinate 1715-33-9 98%
    Prednisolone (sodium succinate) is an anti-inflammatory corticosteroid and a prodrug of the glucocorticoid prednisolone. Prednisolone (sodium succinate) is used as an immunosuppressant.
    Prednisolone sodium succinate
  • HY-W424851
    DPQ hydrochloride 84050-22-6 98%
    DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases.
    DPQ hydrochloride
  • HY-W436270
    Bulbocapnine hydrochloride 632-47-3 98%
    Bulbocapnine hydrochloride, an aporphine alkaloid, is a dopamine receptor inhibitor. Bulbocapnine hydrochloride inhibits dopamine synthesis. Bulbocapnine hydrochloride also has neuroleptic-like, anticonvulsant and antinociceptive effects.
    Bulbocapnine hydrochloride
  • HY-W472153
    β-Glucuronidase-IN-5 7455-77-8 98%
    β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications).
    β-Glucuronidase-IN-5
  • HY-W472451
    Linalyl isobutyrate 78-35-3 98%
    Linalyl isobutyrate is a fragrance ingredient. Linalyl isobutyrate produces very slight erythema.
    Linalyl isobutyrate
  • HY-W474473
    3-(N-Phthalimidoylmethylthio)propanoic acid 91570-07-9 98%
    3-(((1,3-Dioxoisoindolin-2-yl)methyl)thio)propanoic acid (MFP) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 3-(((1,3-Dioxoisoindolin-2-yl)methyl)thio)propanoic acid can be combined with carrier proteins and used in antigen design.
    3-(N-Phthalimidoylmethylthio)propanoic acid
  • HY-W505771
    Seselin 523-59-1 99.55%
    Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active.
    Seselin
  • HY-W511185
    ST026567 5067-25-4 98%
    ST026567 is a potent mast cell activator. ST026567 induces the secretion of PGD2, LTC4 from cells. ST026567 exhibits degranulation potency.
    ST026567
  • HY-W517163
    MK-2295 573678-04-3 98%
    MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain.
    MK-2295
  • HY-W545294
    RORγ-IN-2 2088333-58-6 98%
    RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases.
    RORγ-IN-2
  • HY-W550315
    Dimethyl diacetyl cystinate 32381-28-5 98%
    Dimethyl diacetyl cystinate (DACDM) is a potent NF-κB inhibitor. Dimethyl diacetyl cystinate shifts the intracellular redox balance toward the oxidized state by increasing intracellular oxidized glutathione (GSSG) content, competitively blocking the binding of activated NF-κB to DNA, thereby inhibiting the production of inflammatory factors such as IL-1κ. Dimethyl diacetyl cystinate is promising for research of UVB-induced skin inflammation and related oxidative stress diseases.
    Dimethyl diacetyl cystinate
  • HY-W550739
    Acesulfame 33665-90-6 98%
    Acesulfame is a synthetic sweetener. Long-term use of Acesulfame can affect cognitive function. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion.
    Acesulfame
  • HY-W554021
    S-Carboxymethyl-L-cysteine L-lysine monohydrate 49673-81-6 98%
    S-Carboxymethyl-L-cysteine L-lysine monohydrate (Carbocisteine lysine) is a mucosal active drug with anti-inflammatory and antioxidant activities, which can be used in the research of chronic obstructive pulmonary disease (COPD).
    S-Carboxymethyl-L-cysteine L-lysine monohydrate
  • HY-W556870
    OT-551 627085-15-8 98%
    OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research.
    OT-551
  • HY-W580721
    4-Methylhistamine 36507-31-0
    4-Methylhistamine is a potent and selective agonist of histamine 4 receptor (H4R) with a Ki of 50 nM. 4-Methylhistamine has a >100-fold selectivity for the hH4R over the other histamine receptor subtypes. 4-Methylhistamine can potently activate the hH4R (pEC50 = 7.4). 4-Methylhistamine can be used for the researches of cancer, inflammation and immunology, such as lung cancer and skin inflammation.
    4-Methylhistamine
  • HY-W588257
    (+)-Thienamycin 59995-64-1 98%
    (+)-Thienamycin is a potent broad-spectrum antibacterial and β-lactamase inhibitor that can be from Streptomyces cattleya.
    (+)-Thienamycin
  • HY-W615446
    GSTO1-IN-3 158890-32-5 98%
    GSTO1-IN-3 is a potent GSTO1-1 inhibitor with an IC50 of 0.11 μM, and shows selectivity over GSTO2-2, GSTA1-1 and GSTP1-1 (IC50 > 100 μM). GSTO1-IN-3 enhances the cytotoxicity of Cisplatin (HY-17394) against human breast cancer cells. GSTO1-IN-3 inhibits IL-1β release in mouse bone marrow-derived macrophage (BMDM) cells. GSTO1-IN-3 attenuates inflammation in mice. GSTO1-IN-3 can be used for breast cancer and inflammation research.
    GSTO1-IN-3
  • HY-W635076
    oJak-989 1315485-91-6 98%
    oJak-989 is a selective JAK1 inhibitor with a Ki of 2.8 nM for JAK1, 110 nM for JAK3, and 31 nM for TYK2. oJak-989 is applicable to the research of inflammatory diseases.
    oJak-989
Cat. No. Product Name / Synonyms Application Reactivity