2. Metabolic Enzyme/Protease
  3. β-glucuronidase
  4. β-Glucuronidase-IN-5

β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications).

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β-Glucuronidase-IN-5

β-Glucuronidase-IN-5 Chemical Structure

CAS No. : 7455-77-8

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β-Glucuronidase-IN-5 Related Antibodies

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Description

β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications)[1][2].

Molecular Weight

256.69

Formula

C14H9ClN2O
CAS No.
SMILES

O=C1NC(C2=CC=C(Cl)C=C2)=NC3=C1C=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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β-Glucuronidase-IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Glucuronidase-IN-57455-77-8β-glucuronidaseGUSBQuinazolineβ-glucuronidase inhibitorsIC50cytotoxicityPC-3 cellsD-saccharic acid 1,4-lactoneenzymatic inhibitionsynthesisstructure-activity relationshipInhibitorinhibitorinhibit

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