β-Glucuronidase-IN-5
β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications).
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- CAS 番号: 7455-77-8
- 分子式: C14H9ClN2O
- 分子量:256.69
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Sf21 | IC50 |
54 nM
Compound: 13d
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Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrate addition measured after 30 mins
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[PMID: 27163581] |
化学情報
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CAS 番号 7455-77-8
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分子量 256.69
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分子式 C14H9ClN2O
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SMILES
O=C1NC(C2=CC=C(Cl)C=C2)=NC3=C1C=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Pieterse L, et al. C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127274. [Content Brief]
[2]. Muhammad Iqbal Choudhary, et al. Quinazolines as b-glucuronidase novel inhibitors. US20140256754A1.
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
β-Glucuronidase-IN-5 関連分類
HY-W472153 関連分類
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