7455-77-8
Chemical Structure
β-Glucuronidase-IN-5
- CAS No.: 7455-77-8
- Formula:C14H9ClN2O
- Molecular Weight:256.69
IUPAC Name: 2-(4-chlorophenyl)quinazolin-4(1H)-one
InChIKey: AKHUKZJZNGHOJU-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CC=C(Cl)C=C2)=NC3=C1C=CC=C3
Biological Activity: β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications)[1][2].
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β-Glucuronidase-IN-5 | β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC50 of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC50 > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications). | |||||||||||||||||||||
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References
- [1]. Pieterse L, et al. C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127274. [Content Brief]
- [2]. Muhammad Iqbal Choudhary, et al. Quinazolines as b-glucuronidase novel inhibitors. US20140256754A1.
