Danshenspiroketallactone
Danshenspiroketallactone is a lactone found in the roots of Salvia miltiorrhiza. Danshenspiroketallactone shows no anti-inflammatory and anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 100414-80-0
- Formula: C17H16O3
- Molecular Weight:268.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Danshenspiroketallactone (Compound 22) shows no cytotoxic activity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 human cancer cell lines with IC50 > 40 μM[1].
Danshenspiroketallactone shows no anti-inflammatory activity against LPS (HY-D1056)-induced nitrous oxide production in RAW 264.7 mouse peritoneal macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 100414-80-0
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Molecular Weight 268.31
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Formula C17H16O3
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SMILES
O=C1O[C@]2(OC[C@@H](C2)C)C3=CC=C(C(C)=CC=C4)C4=C31
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Danshenspiroketallactone Related Classifications
HY-W420454 Related Classifications
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