2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107567BR
    Carcinine dihydrochloride (Standard) 57022-38-5 98%
    Carcinine dihydrochloride (Standard) is the analytical standard of Carcinine (dihydrochloride) (HY-107567B). This product is intended for research and analytical applications. Carcinine (β-Alanylhistamine) dihydrochloride is the dihydrochloride salt of Carcinine (HY-107567). Carcinine is a selective and orally active histamine H3 receptor antagonist with a Ki of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes.
    Carcinine dihydrochloride (Standard)
  • HY-107608S1
    Leukotriene B4-d5 98%
    Leukotriene B4-d5 (LTB4-d5) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4-d5
  • HY-107613AR
    R 59-022 hydrochloride (Standard) 93076-98-3 98%
    R 59-022 hydrochloride (Standard) is the analytical standard of R 59-022 (hydrochloride) (HY-107613A). This product is intended for research and analytical applications. R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein Kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
    R 59-022 hydrochloride (Standard)
  • HY-107647AR
    (R)-(+)-Dimethindene maleate (Standard) 136152-64-2 98%
    (R)-(+)-Dimethindene maleate (Standard) is the analytical standard of (R)-(+)-Dimethindene (maleate) (HY-107647A). This product is intended for research and analytical applications. (R)-(+)-Dimethindene maleate is an orally active H1-receptor blocker with antihistaminic properties in pigs.
    (R)-(+)-Dimethindene maleate (Standard)
  • HY-107787AR
    Dioxopromethazine hydrochloride (Standard) 15374-15-9 98%
    Dioxopromethazine hydrochloride (Standard) is the analytical standard of Dioxopromethazine hydrochloride. This product is intended for research and analytical applications. Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms and can be used for relevant research.
    Dioxopromethazine hydrochloride (Standard)
  • HY-108065AR
    3'-Sialyllactose sodium (Standard) 128596-80-5 98%
    3'-Sialyllactose (sodium) (Standard) is the analytical standard of 3'-Sialyllactose (sodium). This product is intended for research and analytical applications. 3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.
    3'-Sialyllactose sodium (Standard)
  • HY-108642BR
    AMG-548 dihydrochloride (Standard) 2518299-32-4
    AMG-548 dihydrochloride (Standard) is the analytical standard of AMG-548 (dihydrochloride) (HY-108642B). This product is intended for research and analytical applications. AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM). AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein Kinase 1 isoforms δ and ε.
    AMG-548 dihydrochloride (Standard)
  • HY-111326AR
    Naphazoline nitrate (Standard) 5144-52-5 98%
    Naphazoline (nitrate) (Standard) is the analytical standard of Naphazoline (nitrate). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research.
    Naphazoline nitrate (Standard)
  • HY-112077AR
    Viaminate (Standard) 53839-71-7
    Viaminate (Standard) is the analytical standard of Viaminate. This product is intended for research and analytical applications. Viaminate is a derivative of Retinoic acid, which is used for the treatment of severe acne and other keratinization disorders.
    Viaminate (Standard)
  • HY-113008BR
    trans-Urocanic acid (Standard) 3465-72-3 98%
    trans-Urocanic acid (Standard) is the analytical standard of trans-Urocanic acid. This product is intended for research and analytical applications. trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function.
    trans-Urocanic acid (Standard)
  • HY-113037AS
    Farnesyl pyrophosphate-d6 895550-58-0 98%
    Farnesyl pyrophosphate-d6 (Farnesyl diphosphate-d6) is a deuterium labeled Farnesyl pyrophosphate (HY-113037B). Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
    Farnesyl pyrophosphate-d6
  • HY-113331S1
    Thromboxane B2-d9 98%
    Thromboxane B2-d9 is deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation.
    Thromboxane B2-d9
  • HY-113402AR
    Gamma-glutamylcysteine TFA (Standard) 283159-88-6 98%
    Gamma-glutamylcysteine (TFA) (Standard) is the analytical standard of Gamma-glutamylcysteine (TFA). This product is intended for research and analytical applications. Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.
    Gamma-glutamylcysteine TFA (Standard)
  • HY-113412AR
    3-Methylhistamine dihydrochloride (Standard) 36475-47-5
    3-Methylhistamine (dihydrochloride) (Standard) is the analytical standard of 3-Methylhistamine (dihydrochloride). This product is intended for research and analytical applications. 3-Methylhistamine dihydrochloride is a degradation product of histamine. 3-Methylhistamine dihydrochloride, a methylated product of histamine, is associated with immune response and shows upregulation in the vaccinated mice.
    3-Methylhistamine dihydrochloride (Standard)
  • HY-113469AR
    Cyclic GMP sodium (Standard) 40732-48-7 98%
    Cyclic GMP sodium (Standard) is the analytical standard of Cyclic GMP sodium (HY-113469A). This product is intended for research and analytical applications. Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
    Cyclic GMP sodium (Standard)
  • HY-113756AR
    Latanoprost acid (Standard) 41639-83-2
    Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
    Latanoprost acid (Standard)
  • HY-118861S1
    Enclomiphene-d4 99.85%
    Enclomiphene-d4 ((E)-Clomiphene-d4) is a deuterium labeled Enclomiphene. Enclomiphen?is a potent and orally active?estrogen receptor?antagonist with antioestrogenic property.
    Enclomiphene-d4
  • HY-119674AR
    Xanthopterin hydrate (Standard) 5979-01-1 98%
    Xanthopterin (hydrate) (Standard) is the analytical standard of Xanthopterin (hydrate). This product is intended for research and analytical applications. Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm. Xanthopterin hydrate(XPT) causes renal growth and hypertrophy in rat. Xanthopterin hydrate inhibits RNA synthesis.
    Xanthopterin hydrate (Standard)
  • HY-119695AR
    Simvastatin acid ammonium (Standard) 139893-43-9 98%
    Simvastatin acid (ammonium) (Standard) is the analytical standard of Simvastatin acid (ammonium). This product is intended for research and analytical applications. Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
    Simvastatin acid ammonium (Standard)
  • HY-121467S1
    Acotiamide-d4 98%
    Acotiamide-d4 (Z-338 (free base)-d4) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
    Acotiamide-d4
Cat. No. Product Name / Synonyms Application Reactivity