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  4. Retinyl acetate

Retinyl acetate  (Synonyms: Retinol acetate; Vitamin A acetate)

Cat. No.: HY-N0679 Pureza: 99.30%
COA
SDS
Instrucciones de manejo Technical Support

Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS : 127-47-9

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
50 mg En stock
100 mg En stock
500 mg En stock
1 g En stock
5 g En stock
10 g En stock
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Revisión del cliente

Based on 4 publication(s) in Google Scholar

Other Forms of Retinyl acetate:

Retinyl acetate Related Antibodies

Top Publications Citing Use of Products

    Retinyl acetate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Jun 16;24(12):10236.

    Cells were treated with or without Retinyl acetate (10 μM) in either NM or HFM for 24 h, and the cells were stained with BODIPY (LDs, green) or DAPI (nuclei, blue). The white box delineates the magnified cells.

    Retinyl acetate purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Jun 16;24(12):10236.

    Relative mRNA expression of lipid metabolism-related genes in cells treated with or without Retinyl acetate (10 μM) in either NM or HFM for 24 h (n = 3). The results showed that Retinyl acetate increased the expression of lipid synthesis-related genes, including pparg, fatty acid-binding protein 1 (fabp1), and fasn, especially in the HFM group.

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities[1].

    In Vitro

    Retinyl acetate (10 μM) inhibits the proliferation of tumor cells (such as melanoma cell lines B 16 and S91, inhibition rate: 48%, 79% respectively)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Retinyl acetate Related Antibodies
    In Vivo

    Retinyl acetate (250 mg/kg in diet) inhibits DMBA (HY-W011845) induced mammary carcinogenesis in the Sprague-Dawley rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Peso molecular

    328.49

    Fòrmula

    C22H32O2
    No. CAS
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\COC(C)=O
    Structure Classification
    Initial Source
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    DMSO : 50 mg/mL (152.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0442 mL 15.2212 mL 30.4423 mL
    5 mM 0.6088 mL 3.0442 mL 6.0885 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (6.33 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 2 mg/mL (6.09 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureza y Documentación

    Purity: 99.48%

    SDS (418 KB)

    COA (241 KB) RP-HPLC (219 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0442 mL 15.2212 mL 30.4423 mL 76.1058 mL
    5 mM 0.6088 mL 3.0442 mL 6.0885 mL 15.2212 mL
    10 mM 0.3044 mL 1.5221 mL 3.0442 mL 7.6106 mL
    15 mM 0.2029 mL 1.0147 mL 2.0295 mL 5.0737 mL
    20 mM 0.1522 mL 0.7611 mL 1.5221 mL 3.8053 mL
    25 mM 0.1218 mL 0.6088 mL 1.2177 mL 3.0442 mL
    30 mM 0.1015 mL 0.5074 mL 1.0147 mL 2.5369 mL
    40 mM 0.0761 mL 0.3805 mL 0.7611 mL 1.9026 mL
    50 mM 0.0609 mL 0.3044 mL 0.6088 mL 1.5221 mL
    60 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2684 mL
    80 mM 0.0381 mL 0.1903 mL 0.3805 mL 0.9513 mL
    100 mM 0.0304 mL 0.1522 mL 0.3044 mL 0.7611 mL
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    Retinyl acetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Retinyl127-47-9RetinolVitamin AEnvironmental PollutantsEnvironmental ContaminantstumorB16anticancerDMBAInhibitorinhibitorinhibit

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    Nombre del producto:
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    Cat. No.:
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