2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cytochrome P450
  5. CYP51 Isoform
  6. CYP51 Inhibitor

CYP51 Inhibitor

CYP51 Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-136063
    Mefentrifluconazole
    		Inhibitor 99.61%
    Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent.
  • HY-B0852
    Tebuconazole
    		Inhibitor 99.66%
    Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
  • HY-17643
    Oteseconazole
    		Inhibitor 99.56%
    Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51.
  • HY-117766
    PC945
    		Inhibitor 99.62%
    PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus.
  • HY-109040
    Quilseconazole
    		Inhibitor
    Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.
  • HY-144643
    CYP51/HDAC-IN-1
    		Inhibitor
    CYP51/HDAC-IN-1 is a potent, orally active CYP51/HDAC dual inhibitor.
  • HY-108938
    SDZ285428
    		Inhibitor 98.04%
    SDZ285428 is a CYP51 inhibitor.
  • HY-N7266
    Obtusifoliol
    		Inhibitor
    Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively.