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Cat. No.: HY-136755

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CYP51-IN-5

CYP51-IN-5 is a cytochrome P450 14α-demethylase (CYP51) inhibitor and an antifungal (fungal) agent belonging to the triazole derivative class. CYP51-IN-5 is applicable to the research of Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei and Microsporum gypseum.

For research use only. We do not sell to patients.

CAS No.: 1155361-03-7
Formula: C₂₁H₂₁ClF₂N₄O
Molecular Weight:418.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CYP51-IN-5 Chemical Structure

CAS No.: 1155361-03-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CYP51

All Cytochrome P450 Isoforms :

In Vitro

CYP51-IN-5 (Compound 1e) (0.0156-1 mg/mL; 24-72 h) exhibits strong to moderate in vitro antifungal activity against most tested human pathogenic fungi (Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei and Microsporum gypseum), with the highest activity against Candida albicans (MIC₈₀ = 0.0156 mg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1155361-03-7
Molecular Weight 418.87
Formula C₂₁H₂₁ClF₂N₄O
SMILES

FC1=CC=C(C(CN2N=CN=C2)(CN(CC3=C(Cl)C=CC=C3)CC=C)O)C(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chai X, et al. Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Eur J Med Chem. 2009;44(5):1913-1920. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CYP51-IN-5

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CYP51-IN-5 Related Classifications

HY-136755 Related Classifications