1. Anti-infection
    Metabolic Enzyme/Protease
  2. Fungal
    Cytochrome P450
  3. PC945

PC945 

Cat. No.: HY-117766
Handling Instructions

PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively.

For research use only. We do not sell to patients.

PC945 Chemical Structure

PC945 Chemical Structure

CAS No. : 1931946-73-4

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5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 3600 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2].

IC50 & Target[1]

fungal

 

CYP51A

0.23 μM (IC50)

CYP51B

0.22 μM (IC50)

In Vitro

PC945 is a triazole antifungal designed for administration via inhalation[1].
PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063 µg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PC945 (0.56-14 μg/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free A/J mice (male, 5 weeks old, pulmonary Aspergillus infection)[1]
Dosage: 0.56, 2.8, 14 μg/mouse (intranasal application of 0.016-, 0.08-, and 0.4-mg/ml suspensions, respectively)
Administration: Intranasal; daily for 7 days
Result: Substantially inhibited the incidence of rolling behavior.
Clinical Trial
Molecular Weight

682.73

Formula

C₃₈H₃₇F₃N₆O₃

CAS No.

1931946-73-4

SMILES

O=C(NC1=CC=C(F)C=C1)C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[[email protected]@H]5CO[[email protected]](C6=CC=C(F)C=C6F)(CN7N=CN=C7)C5)C(C)=C4)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PC945PC 945PC-945FungalCytochrome P450CYPsantifungallong-actinginfectionitraconazole-susceptibleresistantrespiratorytriazoleInhibitorinhibitorinhibit

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PC945
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HY-117766
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