CYP51-IN-32
CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against CYP51 of Candida albicans. CYP51-IN-32 releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development of Candida albicans. CYP51-IN-32 can be formulated into PEG-based nanovesicles. CYP51-IN-32 is applicable to the research of Candida albicans infection.
For research use only. We do not sell to patients.
- CAS No.: 205251-67-8
- Formula: C19H19ClN2OS2
- Molecular Weight:390.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP51 0.331 μM (IC50) |
CYP51-IN-32 (Compound 3j) (PEG-niosome-formulated) potently inhibits Candida albicans growth with an MIC of 4.68 μg/mL[1].
CYP51-IN-32's antifungal activity against Candida albicans is reduced when H2S is scavenged by 1.5 mg/mL MgO, with its MIC rising to 32 μg/mL[1].
CYP51-IN-32 robustly inhibits Candida albicans hyphal formation, maintaining the fungus in its unicellular yeast form[1].
CYP51-IN-32 inhibits Candida albicans biofilm formation by 60% at a concentration of 0.0005 mg/mL[1].
CYP51-IN-32 has an IC50 of 65.73 μg/mL against WS-1 human skin fibroblasts, resulting in a selectivity index of ~14.0 relative to its antifungal MIC against Candida albicans[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 205251-67-8
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Molecular Weight 390.95
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Formula C19H19ClN2OS2
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SMILES
O=C(C1=CC=C(Cl)C=C1)CSC(N(CC2)CCN2C3=CC=CC=C3)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP51-IN-32 Related Classifications
HY-181511 Related Classifications
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