FAK

PTK2 protein tyrosine kinase 2; PTK2; Focal adhesion kinase

FAK

Related Products

FAK (Focal Adhesion Kinase or PTK2) is a non-receptor and non-membrane associated protein tyrosine kinase that is activated at the sites of cell-matrix adhesions and integrin clustering by auto-phosphorylation (at Tyr397), Src, and other tyrosine kinases. FAK mediates integrin-based cell signaling by transferring signals regulating cell migration, adhesion, and survival from the extracellular matrix to the cytoplasm.

FAK is overexpressed in many tumors, including those derived from the head and neck, colon, breast, prostate, liver, and thyroid. Furthermore, FAK overexpression is highly correlated with an invasive phenotype in these tumors. Inhibition of FAK signaling by overexpression of dominant-negative fragments of FAK reduces invasion of glioblastomas and ovarian cancer cells. FAK therefore represents an important target for the development of anti-neoplastic and anti-metastatic drugs.

FAK Related Products (73)
Antibodies (3)

By Effects:	Inhibitors (64) Degrader (1) Activators (3) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-122965

Batatasin III	Inhibitor	99.70%
Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT signals. Batatasin III has anti-cancer activities.

HY-144448

FAK-IN-2	Inhibitor	98.27%
FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC₅₀= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis.

HY-B1305

Chloropyramine hydrochloride	Inhibitor	99.73%
Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3 and FAK.

HY-N10535

Lewis y tetrasaccharide	Activator	≥99.0%
Lewis Y tetrasaccharide (Lewis Y, Le^Y) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis.

HY-148877

AT-533	Inhibitor	98.86%
AT-533 is a potent Hsp90 and HSV inhibitor. AT-533 suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway. AT-533 also inhibits the activation of the downstream pathways, including Akt/mTOR/p70S6K, Erk1/2 and FAK. AT-533 inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).

HY-148109

FAK-IN-7	Inhibitor	98.55%
FAK-IN-7 (compound 5r) is a FAK inhibitor (IC₅₀=11.72 µM). FAK-IN-7 has good anti-proliferative activity and can be used in cancer research.

HY-145108

FAK-IN-1	Inhibitor
FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).

HY-148070

FLT3-IN-17	Inhibitor	99.56%
FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC₅₀s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC₅₀ value of 12 nM. FLT3 ligand-2 can be used in the research of cancers.

HY-A0280

Roslin 2 bromide		≥99.0%
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53.

HY-20403

PF-562271 hydrochloride	Inhibitor
PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC₅₀s of 1.5 nM and 13 nM, respectively.

HY-102073

TG53	Inhibitor
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research.

HY-103471

Y11
Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth.

HY-147520

FAK-IN-5	Inhibitor
FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy.

HY-144794

EGFR-IN-46	Inhibitor
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC₅₀s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis.

HY-143407

FAK-IN-3	Inhibitor
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer.

HY-146065

FAK-IN-4	Inhibitor
FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis.

HY-143458

FAK PROTAC B5	Inhibitor
FAK PROTAC B5 (Compound B5) is a FAK PROTAC degrader with an IC₅₀ value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion.

HY-162034

FAK-IN-17	Inhibitor
FAK-IN-17 is a focal adhesion kinase (FAK) inhibitor. FAK-IN-17 possesses anticancer activity against A549 and MDA-MB-231 cell lines with IC₅₀ values of 130 nM and 94 nM.

HY-161358

FAK-IN-20	Inhibitor
FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC₅₀ value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. It can arrest the cell cycle in the G2/M phase and induce cell apoptosis (apoptosis) by generating ROS.

HY-12289S

Defactinib-d₆	Inhibitor
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

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FAK

FAK

FAK Related Products (73)

Antibodies (3)

FAK Related Products (73):