EGFR-IN-46
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2764772-88-3
- Formula: C27H32F3N3O3
- Molecular Weight:503.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
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EGFR 20.17 nM (IC50) |
FAK 14.25 nM (IC50) |
EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 µM, respectively[1].
EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells[1].
EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively.
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Cell Line:DLD1 cells
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Concentration:3 µM
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Incubation Time:24 h
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Result:Increased the total percentage of apoptotic cells from 7% to 90.33%.
Chemical Information
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CAS No. 2764772-88-3
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Molecular Weight 503.56
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Formula C27H32F3N3O3
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SMILES
COC1=C(C=C2C(N=C(C=C2OCCCNC3CCN(CC3)C)C4=CC=C(C=C4)C(F)(F)F)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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