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Cat. No.: HY-144794

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EGFR-IN-46

EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC₅₀s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis.

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CAS No.: 2764772-88-3
화학식: C₂₇H₃₂F₃N₃O₃
분자량:503.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EGFR-IN-46 Chemical Structure

CAS No.: 2764772-88-3

Amount: USD 0.00

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

EGFR

20.17 nM (IC₅₀)

FAK

14.25 nM (IC₅₀)

All EGFR Isoforms :

In Vitro

EGFR-IN-46 (compound 6h) (0-100 µM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC₅₀s of 1.79, 3.28 µM, respectively^[1].
EGFR-IN-46 (3 µM; 24 h) induces cell apoptosis in DLD1 cells^[1].
EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells
Concentration:

10 µM
Incubation Time:

24 h
Result:

Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively.

Apoptosis Analysis^[1]

Cell Line:

DLD1 cells
Concentration:

3 µM
Incubation Time:

24 h
Result:

Increased the total percentage of apoptotic cells from 7% to 90.33%.

Related Protocols :

Chemical Information

CAS No. 2764772-88-3
분자량 503.56
화학식 C₂₇H₃₂F₃N₃O₃
SMILES

COC1=C(C=C2C(N=C(C=C2OCCCNC3CCN(CC3)C)C4=CC=C(C=C4)C(F)(F)F)=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elbadawi MM, et al. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37(1):349-372. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

EGFR-IN-46

All EGFR Isoforms