FAK-IN-4
FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 3032200-62-4
- Formula: C20H22N4O
- Molecular Weight:334.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
40.63 μM
Compound: 7d
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-157 | IC50 |
12.09 μM
Compound: 7d
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Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-231 | IC50 |
8.37 μM
Compound: 7d
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
| MDA-MB-453 | IC50 |
9.07 μM
Compound: 7d
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Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 35569251] |
FAK-IN-4 (Compound 7d) (0-200 μM, 72 h) shows antiproliferative activity against triple-negative breast cancer (TNBC) cells[1].
FAK-IN-4 (0-20 μM, 24 h) inhibits cell invasion and migration of MDA-MB-231 cells[1].
FAK-IN-4 (0-20 μM, 72 h) causes dose-dependent Y925 dephosphorylation of FAK, and induces apoptosis in MDA-MB-231 cells[1].
FAK-IN-4 inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A
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Concentration:0.78, 1.56, 3.13, 5, 6.25, 100, 12.5, 25, 50, 100 and 200 μM
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Incubation Time:72 h
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Result:Inhibited the growth of TNBC cells with IC50 values of 8.37, 12.09, 9.07 and 40.63 μM against MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A cells.
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Cell Line:MDA-MB-231
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Concentration:5, 10 and 20 μM
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Incubation Time:24 h
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Result:Significantly inhibited the invasion of MDA-MB-231 cells in a dose-dependent manner.
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Cell Line:MDA-MB-231
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Concentration:5, 10 and 20 μM
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Incubation Time:72 h
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Result:Caused an obvious dose-dependent Y925 dephosphorylation of FAK.
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Cell Line:MDA-MB-231
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Concentration:5, 10 and 20 μM
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Incubation Time:72 h
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Result:Increased the percentage of apoptotic MDA-MB-231 cells ranging from 13.10% to 41.59% in a dose-dependent manner.
Chemical Information
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CAS No. 3032200-62-4
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Molecular Weight 334.41
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Formula C20H22N4O
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SMILES
CN(CCN(C1=NC=CC=C1)C(/C=C/C2=CNC3=C2C=CC=C3)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAK-IN-4 Related Classifications
HY-146065 Related Classifications
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