2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FAK Apoptosis
  4. FAK-IN-4

FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis.

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FAK-IN-4 Chemical Structure

FAK-IN-4 Chemical Structure

CAS No. : 3032200-62-4

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FAK-IN-4 Related Antibodies

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Description

FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis[1].

In Vitro

FAK-IN-4 (Compound 7d) (0-200 μM, 72 h) shows antiproliferative activity against triple-negative breast cancer (TNBC) cells[1].
FAK-IN-4 (0-20 μM, 24 h) inhibits cell invasion and migration of MDA-MB-231 cells[1].
FAK-IN-4 (0-20 μM, 72 h) causes dose-dependent Y925 dephosphorylation of FAK, and induces apoptosis in MDA-MB-231 cells[1].
FAK-IN-4 inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAK-IN-4 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A
Concentration: 0.78, 1.56, 3.13, 5, 6.25, 100, 12.5, 25, 50, 100 and 200 μM
Incubation Time: 72 h
Result: Inhibited the growth of TNBC cells with IC50 values of 8.37, 12.09, 9.07 and 40.63 μM against MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A cells.

Cell Invasion Assay[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 24 h
Result: Significantly inhibited the invasion of MDA-MB-231 cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 72 h
Result: Caused an obvious dose-dependent Y925 dephosphorylation of FAK.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 5, 10 and 20 μM
Incubation Time: 72 h
Result: Increased the percentage of apoptotic MDA-MB-231 cells ranging from 13.10% to 41.59% in a dose-dependent manner.
Molecular Weight

334.41

Formula

C20H22N4O
CAS No.
SMILES

CN(CCN(C1=NC=CC=C1)C(/C=C/C2=CNC3=C2C=CC=C3)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FAK-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-43032200-62-4FAKApoptosisPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseMDA-MB-231MDA-MB-157MDA-MB-453MCF10AanticancerInhibitorinhibitorinhibit

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