1. Apoptosis
  2. MDM-2/p53
  3. Roslin 2 bromide

Roslin 2 bromide (Synonyms: Benzylhexamethylenetetramine bromide)

Cat. No.: HY-A0280
Handling Instructions

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53.

For research use only. We do not sell to patients.

Roslin 2 bromide Chemical Structure

Roslin 2 bromide Chemical Structure

CAS No. : 29574-21-8

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Description

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

In Vitro

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

311.22

Formula

C13H19BrN4

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Roslin 2 bromide
Cat. No.:
HY-A0280
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