2. Protein Tyrosine Kinase/RTK Apoptosis Autophagy
  3. FAK Apoptosis Autophagy
  4. FAK-IN-5

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy.

For research use only. We do not sell to patients.

FAK-IN-5 Chemical Structure

FAK-IN-5 Chemical Structure

CAS No. : 2408317-70-2

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FAK-IN-5 Related Antibodies

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Description

FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy[1].

In Vitro

FAK-IN-5 (Compound 8l) (0-50 µM, 72 h) shows antiproliferative activity against cancer cells[1].
FAK-IN-5 (Compound 8l) causes cell detachment[1].
FAK-IN-5 (Compound 8l) (0-25 µM, 24 h) induces autophagy and apoptosis in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAK-IN-5 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: K562, CEM, G361, MCF-7 and HCT-116
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50 values of 6.3, 7.9, 6.3, 5.5 and 5.3 µM against K562, CEM, G361, MCF-7 and HCT-116 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT-116
Concentration: 1.25, 2.5, 5, 7, 10, 11, 17 and 25 µM
Incubation Time: 1, 3, 5, 7 and 24 h
Result: Caused the dephosphorylation of FAK, p130Cas and paxillin in a dose-dependent manner. The dephosphorylation of FAK at Y397 was observed at a much earlier time point. Detected the fragments of activated caspase-7 as well as the dose-dependent cleavage of poly (ADP-ribose) polymerase (PARP).
Molecular Weight

576.01

Formula

C29H29ClF3N3O4
CAS No.
SMILES

CC(C[C@@H](C(N[C@H](C(NC1=CC=C(C=C1)C(F)(F)F)=O)CC2=CC=CC=C2)=O)NC(C3=CC(Cl)=CC=C3O)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FAK-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-52408317-70-2FAKApoptosisAutophagyPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseK562CEMG361MCF-7HCT-116anticancerInhibitorinhibitorinhibit

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