FAK-IN-20
FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC50 value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. FAK-IN-20 can arrest the cell cycle in the G2/M phase and induce cell apoptosis by generating ROS.
For research use only. We do not sell to patients.
- CAS No.: 3004967-41-0
- Formula: C27H34ClN7O5S
- Molecular Weight:604.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.27 nM (FAK)[1].
FAK-IN-20 (Compound 7b) (72 h) can inhibit cell proliferation in human tumor cell lines such as HCT116 (colon cancer), A549 (lung cancer), MDA-MB-231 (breast cancer), and HeLa (cervical cancer) with IC50 values of 0.58, 0.75, 1.18, and 1.4 μM, respectively, demonstrating anticancer activity[1].
FAK-IN-20 (0.2-2 μM; 24 h) arrests the cell cycle in the G2/M phase in HCT116 cells and (0.2-25 μM; 12 h) induces apoptosis by (1-125 μM; 12 h) triggering ROS production[1].
FAK-IN-20 (1 μM; 24 h) inhibits cell migration in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3004967-41-0
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Molecular Weight 604.12
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Formula C27H34ClN7O5S
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SMILES
O=C(NC)C1=CC=CC=C1NC2=C(Cl)C=NC(NC3=C(OC)C=C(NS(CCN4C[C@@H](C)O[C@@H](C)C4)(=O)=O)C=C3)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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