2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-124952
    iKIX1
    		Inhibitor 99.76%
    iKIX1 is an antifungal agent and resensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection.
    iKIX1
  • HY-B2033S
    Pyrimethanil-13C,15N2
    		Inhibitor 99.91%
    Pyrimethanil-13C,15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-W014665
    N-Phthaloylglycine
    		Inhibitor 99.95%
    N-Phthaloylglycine (Phthaloyl glycine) is a Type II fragmentary hapten (FX-type) with antimicrobial activity. N-Phthaloylglycine acts against Candida albicans, Escherichia coli, and Staphylococcus epidermidis. N-Phthaloylglycine can be used for the research of fungal and bacterial infection.
    N-Phthaloylglycine
  • HY-15660S
    Efinaconazole-d4
    		Inhibitor 99.87%
    Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species.
    Efinaconazole-d<sub>4</sub>
  • HY-121770
    Rutarin
    		Inhibitor 99.84%
    Rutarin is a Coumarin (HY-N0709) derivative with antimalarial and antifungal activities. Rutarin inhibits Plasmodium falciparum with an IC50 of 88 μg/mL. Rutarin also inhibits Coniophora cerebella.
    Rutarin
  • HY-153410
    Antifungal agent 49
    		Inhibitor
    Antifungal agent 49 (Example 112) is an antifungal agent. Antifungal agent 49 is active against Cryptococcus neoformans with a MIC value of 49 μM.
    Antifungal agent 49
  • HY-B0896R
    Triacetin (Standard)
    		Inhibitor
    Triacetin (Standard) is the analytical standard of Triacetin. This product is intended for research and analytical applications. Triacetin is a synthetic compound that is a triester of glycerol and acetic acid.
    Triacetin (Standard)
  • HY-133951
    4',6,7-Trimethoxyisoflavone
    		Inhibitor
    4',6,7-Trimethoxyisoflavone is an isoflavone with antimicrobial activities against a wide range of bacteria and fungi. 4',6,7-Trimethoxyisoflavone also has antioxidant effects.
    4',6,7-Trimethoxyisoflavone
  • HY-12772R
    Hydroxy Itraconazole (Standard)
    		Inhibitor
    Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent.
    Hydroxy Itraconazole (Standard)
  • HY-106784A
    (E)-Ajoene
    		Inhibitor
    (E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region.
    (E)-Ajoene
  • HY-159104
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume
    		Inhibitor
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume is a antifungal agent against fungi causing respiratory tract mycoses.
    Cinnamon bark oil, from Cinnamonum zeylanicum Blume
  • HY-P0263A
    Dermaseptin TFA
    		Inhibitor 99.21%
    Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration.
    Dermaseptin TFA
  • HY-101401R
    3-(Methylthio)propionic acid (Standard)
    		Inhibitor
    3-(Methylthio)propionic acid (Standard) is the analytical standard of 3-(Methylthio)propionic acid. This product is intended for research and analytical applications. 3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
    3-(Methylthio)propionic acid (Standard)
  • HY-N6243
    Veratrosine
    		Inhibitor 99.0%
    Veratrosine is a Trihydroxynapthalene reductase (THR) inhibitor and fungal plant pathogen inhibitor. Veratrosine interacts with THR, an enzyme in the DHN melanin biosynthesis pathway of Curvularia lunata. Veratrosine can be used for the research of leaf blight of rice, brown spot of rice, and blast disease of foxtail millet.
    Veratrosine
  • HY-B1878R
    Faltan (Standard)
    		Inhibitor
    Faltan (Standard) is the analytical standard of Faltan. This product is intended for research and analytical applications. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells.
    Faltan (Standard)
  • HY-W010243
    Methylisothiazolinone hydrochloride
    		Inhibitor 99.93%
    Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
    Methylisothiazolinone hydrochloride
  • HY-W010201R
    Citronellol (Standard)
    		Inhibitor
    Citronellol (Standard) is the analytical standard of Citronellol. Citronellol (Standard) is an orally active inducer of apoptosis. Citronellol (Standard) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol (Standard) can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol (Standard) can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol (Standard) exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
    Citronellol (Standard)
  • HY-119606
    Bacimethrin
    		Inhibitor 98.11%
    Bacimethrin (NSC 66577) is an antibacterial agent and is thiamin biosynthesis antagonist.Bacimethrin inhibits bacterial and yeast growth.
    Bacimethrin
  • HY-148160A
    Diamthazole hydrochloride
    		Inhibitor 99.86%
    Diamthazole (Dimazole) hydrochloride is an antifungal agent. Diamthazole hydrochloride can be used for the research of infection.
    Diamthazole hydrochloride
  • HY-B0105S1
    Ketoconazole-d4
    		Inhibitor 99.63%
    Ketoconazole-d4 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity